Comparative hypolipidemic efficacy of homeopathic mother tincture Allium Sativa Q, Curcuma Longa Q and statin in normal and cholesterol fed rabbits

Abstract

Although, lipid lowering drugs regulate the blood serum lipids, they have several reported side effects. Therefore, a substance that is less toxic and yet effective would be beneficial. Here, we compared the antihypercholesterolemic effects of combinations of homeopathic mother tincture (HMT) Allium sativa Q (garlic) and Curcuma longa Q (turmeric), with standard lipid lowering drug statin. For experimentation, a total of 20 rabbits were recruited and divided into four groups with five rabbits (n = 5). Normal saline (NS) group served as control; second group served as high fat diet (HFD) group, third group received Allium sativa Q (garlic) and Curcuma longa Q (turmeric) and HFD (T and G group) while the fourth group received statin and HFD (statin group). At the end of the 8th week, blood was collected to analyze the comparative efficacy of Allium sativa Q, Curcuma longa Q and statin on total cholesterol (TC), low density lipoproteins (LDL), high density lipoproteins (HDL) and triglyceride (TG). Various parameters measured (mg/dl) in HFD rabbits were, TC (291.76±2.2), LDL (244.20±8.3) and triglycerides (243.79±4.3) increased significantly and HDL (32.19±3.3) was reduced to an alarming level as compared to the NS group after eight weeks. TC, LDL and triglycerides level reduced significantly in Tand G group while the HDL level increased significantly as compared to HFD. In statin group, TC (148.37±1.2), LDL (76.32 ±3.4) and TG (104.33 ±8.9) decreased while HDL increased (p LESS than 0.05) as compared to the HFD after eight weeks. It was therefore concluded that that homeopathic medicine Allium sativa Q and Curcuma longa Q is equally good like statin and can safely be used to regulate the circulating serum lipid profile

Reference Values for Selected Blood Parameters in Rabbits: Effects of Age and Physiological Status

“…Rabbits have significant economic importance, both in livestock and pet industry (DG Health and Food Safety, 2017). Moreover, this species is also used frequently as an animal model for studying infectious (Bansal et al, 2014;Peng et al, 2015) and non-infectious diseases (Anjum et al, 2019;Fan et al, 2014), due to several advantages such as easier housing and handling over larger species of animals. Blood parameters represent a great diagnostic tool for animal health status and disease evaluation (Barkakati et al, 2015;Etim et al, 2013;Kumar et al, 2010).…”