Reference Values for Selected Blood Parameters in Rabbits: Effects of Age and Physiological Status

Abstract

Rabbit is widely used as an experimental animal model in infectious and non-infectious diseases. The haematologic data can be helpful in evaluating the health status of animals over time. The aim of this study was to determine the levels of red blood cells (RBC), white blood cells (WBC) and differential leukocyte counts in 5 nulliparous and 5 multiparous females, i.e. in young and older animals, at mating and at delivery. The values of RBC did not change with age, but WBC and lymphocytes decreased with age, a -33% and a -60% less in multiparous females than nulliparous ones. Monocytes count was double at delivery than at mating. In conclusion, aging on the immune system is manifested as reduction in production of mature lymphocytes and as a result, older females would not respond to immune challenge as robustly as the young ones. Physiological status is only related to production of monocytes.

Influences of 6-furfuryloaminopurine on Peripheral T Lymphocyte Subpopulations and Apoptosis of Thymus Lymphocytes of Aging Rats

“…Lymphoid stem cells differentiating in bone marrow develop to T cells primarily in thymus and spleen. There was a positive correlation between the number of lymphocytes and the immunity of the body (Dar et al, 2018, Argente et al, 2019. With the aging of body, The amount of T cells declines and the immune decline (Chason et al, 2018).The number and subpopulations of T cells in peripheral blood also change which results in the decrease of CD 3 + 0CD 4 + and CD 8 + T cells (Coiffard et al, 2018, Ilienko et al, 2017, Sanderson and Simon, 2017.…”

Acute and Chronic Effects of Aluminum Smelter Dust on Hematology, Metal Bioaccumulation and Oxidant-antioxidant Status in Rat

“…Hematological techniques are the most common methods to detect stress and pollutant induced physiological changes. Animal studies have shown that aluminum is implicated as a contributing factor and an etiologic agent in anemia (Adham et al, 2011;Geyikoglu et al, 2013;Muayad et al, 2018;Argente et al, 2019). Effects of aluminum on liver and kidney functions in rat were evidenced by the increased serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine (Geyikoglu et al, 2013;Balgoon, 2019).…”