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A 43-year-old woman, presented with a tender mobile lump in the lower inner quadrant of the left breast. On examination, there was no local lymphadenopathy. Mammography showed a 20 mm, dense, well circumscribed lesion suggesting a fibroadenoma (Fig. 1). The lump was excised and no axillary dissection was made.Grossly, the specimen excised measured 35 · 25 · 15 mm, it was occupied by a well circumscribed, yellow, firm mass. No areas of necrosis were identified.At histological examination (Fig. 2), the tumor had well-defined margins. It was composed of an adipocytic proliferation presenting a variation in cell size with focal nuclear atypia and hyperchromasia. Scattered atypical, hyperchromatic stromal cells were noted in a fibrillary, collageneous stroma. Occasionally, a varying number of monovacuolated or multivacuolated lipoblasts were recognized. An arborizing Figure 2. Associated osteoclast-like giant cells (arrows).Figure 3. Tumor cells were synaptophysin positive whereas the osteoclast-link giant cells were negative (arrow).

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We investigate the expression and localization of the tumor suppressor protein pVHL as well as the oncoprotein Aurora A kinase in kidney cancer. Both Aurora A kinase and pVHL protein status were evaluated using immunohistochemistry. The Aurora A expression is correlated with the Fuhrman grade and the TNM stage, while the pVHL expression is correlated with the capsule rupture and the TNM stage. Aurora A kinase expression increases in malignant tissue comparing to the non-malignant one. And there is a decrease in pVHL expression from the adjacent healthy tissues to the tumor`s ones. The two kinds of opposite tumor profiles display significant distribution difference according to TNM stages. It could be proposed that the absence of Aurora A protein associated with a strong expression of pVHL in clear cells kidney carcinoma are of good prognosis for the disease.

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