La tumeur trichilemmale proliférante maligne

Driss, Maha; Bacha, Dhouha; Mrad, Karima; Charfi, Lamia; Abbès, Imen; Sassi, Samia; Sallemi, Ryme; Romdhane, Khaled Ben

doi:10.1016/s0242-6498(07)78277-9

Cited by 4 publications

(8 citation statements)

References 8 publications

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“…Presence of zones of necrosis with a strong mitotic activity and marked cytonuclear atypies could be providers of malignancy. However, for most authors, only clear infiltration of the stroma confirms this malignancy [2,12]. Benign PTC would strongly express CK10 and involucrine while in malignant form there would be a high number of cells expressing nuclear proliferation cell antigen and CK16 with loss of CD34 expression [2].…”

Section: Discussionmentioning

confidence: 99%

Proliferating Trichilemmal Cyst of the Scalp: 9 Cases and Literature Review

J¹

2018

IJTPS

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Background: Proliferating trichilemmal cyst (PTC) is a rare adnexal tumor, primarily sitting on the scalp of elderly women. Its evolution is generally benign despite the rare malignant cases described. We report a series of 9 cases of which one is malignant and metastatic. Material and methods: We retrospectively reviewed data of all patients with PTC seen at department of dermatology in the Meknes military hospital, between January 2013 and December 2017. Results: 9 cases of PTC were diagnosed, which 8 in elderly women, with 62 years mean age. Trauma was found in one third of cases correlated with rapid growth of the tumor. The latter was symptomatic in 2/3 of the cases. Ulceration involved only the malignant case. The size varied from 1,5 to 12 cm. Recurrence after surgery was noted in 2 cases (malignant tumor and multi-cystic tumor). Discussion: PTC appears to have a well-distinguished profile of the simple trichilemmal cyst. Some clinical and histological features may constitute prognostic factors of aggressiveness. Histological and immunohistochemical study is crucial in the management. A large excision remains the only guarantee of complete remission without recurrence or metastasis. Conclusion: PTC remains misdiagnosed and very few series are reported. Prospective studies would allow the identification of prognostic factors of malignancy as well as better management.

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Section: Discussionmentioning

confidence: 99%

Proliferating Trichilemmal Cyst of the Scalp: 9 Cases and Literature Review

J¹

2018

IJTPS

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“…Indeed, malignant proliferating trichilemmal tumor (also called trichilemmal carcinoma) was first described by Saida in 1983 [ 4 ], due to a PTT that showed infiltrative growth, marked cytological atypia, high mitotic activity including atypical forms and lymph node metastasis [ 2 , 5 ]. Since then, only about sixty well-documented cases have been published in the literature, [ 2 ] some of which are associated with lymph node metastasis and more rarely hematogenous metastasis [ 3 , 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, marked cellular atypia associated with high mitotic activity can be observed in benign PTT. Conversely, typical cases of histologically quiescent PTT had a fatal course [ 6 , 10 ]. Thus, it is currently accepted that only the presence of frank stromal infiltration confirms malignancy [ 3 , 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, typical cases of histologically quiescent PTT had a fatal course [ 6 , 10 ]. Thus, it is currently accepted that only the presence of frank stromal infiltration confirms malignancy [ 3 , 5 , 6 ]. According to Mehregan, the rapid and sudden development of PTT is a clinical predictor of malignancy [ 6 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Its malignant transformation is very rare and unusual, usually evidenced by regional or distant metastasis [ 3 , 4 ]. Indeed, only about sixty cases have been found in the literature [ 5 , 6 ]. We will present an exceptional case associating an invasive malignant frontal trichilemmal carcinoma and a basal cell carcinoma occurring on actinic keratosis lesions, and we will explain the diagnostic, therapeutic and prognostic modalities of this entity.…”

Section: Introductionmentioning

confidence: 99%

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Association of trichilemmal and basal cell carcinomas: a case report

Mekkaoui¹,

Bouchra²,

Amraoui³

et al. 2022

Pan Afr Med J

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Proliferating trichilemmal tumor (PTT) is a benign tumor arising from the isthmic portion of the hair follicle. Malignant transformation in PPT is very rare and unusual. Indeed, only about sixty well-documented cases have been found in the English literature. We present here the case of a 72-year-old patient with an exceptional combination of malignant trichilemmal carcinoma and basal cell carcinoma, occurring on actinic keratosis lesions. The aim of this work is to describe the diagnostic and therapeutic modalities of this association which is exceptional.

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