Une tumeur rénale à connaître : le carcinome tubulomucineux et fusiforme

A case of a 30-year-old female patient diagnosed with mucinous tubular and spindle cell carcinoma (MT&SCC) of her left kidney of the basis of an abdominal ultrasound scan performed when nonspecific pain is presented. The histopathology report revealed a classic type of MT&SCC. Photographs of histopathological samples are shown. Nephrectomy was applied as sole treatment. A follow-up of six years confirmed surgery to be a sufficient approach. The discussion presents a review of up to date world literature concerning the histopathological features, prognosis, and treatment of MT&SCC.

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“…[3, 3, 5, 11] This was also true of this patient, who has developed a large mass of tumor before any symptoms were noted.…”

Section: Discussionmentioning

confidence: 59%

“…[2, 3; 5–9] It does not express kidney-specific cadherin (Ksp-cad), typical of the ascending loop of Henle cells [10]. Ours is a case of a “classic” MT&SCC.…”

Section: Discussionmentioning

confidence: 99%

Mucinous tubular and spindle cell carcinoma

et al. 2012

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“…MTSCC with sarcomatoid differentiation has a poor prognosis despite the low malignant potential of MTSCC, with widespread metastasis to lymph nodes, bones and lungs in approximately 55.4% of the cases (5, 18). Distinction of the sarcomatoid histology from the inherent spindle cell component of MTSCC is important because of its unfavourable prognostic implication (18, 19).…”

Section: Discussionmentioning

confidence: 99%

“…Distinction of the sarcomatoid histology from the inherent spindle cell component of MTSCC is important because of its unfavourable prognostic implication (18, 19). Dhillon et al (5) and Bulimbasic et al (20) have reported 5 cases of the sarcomatoid variant of MTSCCs with aggressive behaviour, of which distant metastases with fatal outcome were seen in 3 cases (20).…”

Section: Discussionmentioning

confidence: 99%

Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney With Sarcomatoid Dedifferentiation

Akhtar

Agnihotri

Alam

et al. 2016

jkcvhl

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Mucinous tubular and spindle cell carcinoma (MTSCC) is a recent entity introduced in the World Health Organization 2004 Classification. It is a tumour of low malignant potential. MTSCC is a subtype of renal cell carcinoma (RCC), which is characterized by a polymorphous histology, wherein the spindled epithelial cell is an inherent carcinomatous component. We report the case of a 57-year-old man presenting with loin pain and dragging sensation. Imaging revealed a large mass arising from the left kidney. Radical nephrectomy was performed, and histopathology revealed spindle cell elements of MTSCC with low-grade cytology, which occasionally blended with tubular structures in variable mucinous stroma admixed with spindle sarcomatoid cells with marked nuclear pleomorphism, associated with significant necrosis and mitoses of up to 5/10 high-power field. A final diagnosis of MTSCC along with high-grade areas consistent with sarcomatoid dedifferentiation was made. Sarcomatoid dedifferentiation has been well documented in various subtypes of RCC, and its presence signifies a worse prognosis in RCC.

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Renal mucinous tubular and spindle cell carcinoma: two cases report and review of the literature

Wei

Zhang

et al. 2012

Chin. -Ger. J. Clin. Oncol.

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Une tumeur rénale à connaître : le carcinome tubulomucineux et fusiforme

Cited by 3 publications

References 3 publications

Mucinous tubular and spindle cell carcinoma

Mucinous tubular and spindle cell carcinoma

Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney With Sarcomatoid Dedifferentiation

Renal mucinous tubular and spindle cell carcinoma: two cases report and review of the literature

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