Signet‐ring cell follicular adenoma of the thyroid

Sassi, Samia; Tangour, Monia; Mrad, Karima; Abbès, Imen; Amor, H; Romdhane, Khaled Ben

doi:10.1111/j.1600-0463.2009.02572.x

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…In this particular case, immunohistochemistry findings point toward TG accumulation in the cytoplasm as a vital a role in SRC formation. This is consistent with the reported results of several other studies [ 10 , 11 , 15 , 18 ]. However, mucin enrichment, dysfunctional swollen endoplasmic reticulum or Golgi apparatus [ 9 ], and degenerate mitochondria [ 15 ] could also lead to the nuclei being pushed to the side of the cell.…”

Section: Introductionsupporting

confidence: 94%

“…Follicular cells in the thyroid tissue may undergo squamous, oncocytic, or clear cell metaplasia. Of these, the clear cell change with signet ring is the least common variant [ 9 , 10 ]. The thyroid signet ring cell (SRC) variant refers to the intracytosolic accumulation of thyroglobulin (TG) [ 11 ], mucin [ 11 – 13 ], lipids [ 11 , 13 ], glycogen [ 11 ], inclusions [ 14 ], lipofuscin, hemosiderin [ 13 ], and other substances [ 15 ] in thyrocytes.…”

Section: Introductionmentioning

confidence: 99%

“…The contents of the vacuoles are colorless or mildly eosinophilic. The nuclei are pushed into a crescent shape, and the whole cell shows a signet-ring appearance [ 10 ]. The presence of SRCs in the thyroid may indicate a primary thyroid disease, such as SRC follicular adenoma, papillary thyroid carcinoma, or metastatic SRC carcinoma [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although it is relatively rare for malignancies to metastasize to the thyroid gland, it is important to distinguish metastatic tumors from primary thyroid lesions [ 8 ]. In this case, thyroglobulin and TTF-1, which are the thyroid reliable origin markers [ 10 , 15 , 19 , 20 ], were identified by immunohistochemistry in the HFCs, and there were no capsule, the follicular hyperplasia was diffuse, some HFCs showed SRC differentiation in combination with the low tumor atypia (as evidenced by the limited growth of tumor cells, lack of obvious mitosis and blood vessel invasion, and absence of tumor-like cells in other organs), resulting in the comprehensive diagnosis of congenital goiter with areas of SRC differentiation.…”

Section: Introductionmentioning

confidence: 99%

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Congenital goiter with areas of signet ring cell differentiation in a juvenile giraffe: a very rare entity

et al. 2020

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Background Congenital goiter is a common thyroid metabolic disorder characterized by low levels of thyroid hormone, subsequent secretion of excess thyroid-stimulating hormone (TSH) from the pituitary gland, and compensatory hyperplasia of the glands. The presence of signet ring cells (SRCs) does not provide sufficient evidence for the diagnosis of a thyroid tumor, making histopathological diagnosis challenging. In addition, SRCs can also appear in congenital goiter. Therefore, a comprehensive diagnosis of congenital goiter is warranted based on clinical symptoms, autopsy, histopathology, and laboratory examination. Case presentation A juvenile giraffe at the Ordos Zoo in Ordos presented with symptoms of loss of appetite, serious salivation, and slow growth rate since birth. Its height and weight were significantly lower than those of other giraffes of the same age. The animal ultimately died at 17 months of age. Autopsy revelaed that the thyroids were hard, with an uneven surface and with the presence of many small raised follicles, and dense in cross-section. Other organs were visibly atrophic. Histopathologically, diffuse follicles were irregular in size and shape in the hyperplastic goiter. Some follicles were collapsed due to lack of colloids. The follicles were lined by single or multiple layers of hyperplastic follicular cells (HFCs), some of which were exfoliated in the lumen. The HFCs were either cuboidal with eosinophilic cytoplasm and many red small granules or showed SRC differentiation, with nuclei pressed to one edge of the cell and distorted by cytoplasmic mucin that appeared as a single clear vacuole HFCs and as a foamy, multivesicular cytoplasmic material in others. Scattered necrosis of myocardial cells and hepatocytes, cerebral hemorrhage, necrosis of intestinal villi, and obvious atrophy of organs were also observed. Immunohistochemical tests were strongly positive for thyroglobulin and thyroid transcription factor-1 (TTF-1) in the cytoplasm of HFCs. Conclusions Here we present a case of congenital goiter with areas of SRC differentiation in the thyroid of a juvenile giraffe.

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Section: Introductionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Congenital goiter with areas of signet ring cell differentiation in a juvenile giraffe: a very rare entity

et al. 2020

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Follicular Thyroid Carcinoma with Signet Ring Cell Morphology: Fine-Needle Aspiration Cytology, Histopathology, and Immunohistochemistry

et al. 2013

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Thyroid follicular neoplasms with signet ring cell morphology represent a challenging cytological and histopathologic diagnosis. The low frequency of these neoplasms and their broad differential diagnosis contribute to this difficult scenario. Here, we present an exceptionally rare case of thyroid follicular carcinoma with signet ring cell morphology in a 62-year-old female. We analyze the characteristics in fine-needle aspiration cytology, histopathology, and immunohistochemistry and compare our results in a discussion with previous literature reports.

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Rare Metastasis of Gastric Cancer to the Thyroid Gland: A Case Report and Review of Literature

Guo

et al. 2021

Front. Surg.

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Background: It is common for patients with gastric cancer to develop distant metastases in the liver, lung, bone, and brain. Although the thyroid also has an abundant blood supply, gastric cancer metastasis to the thyroid is uncommon. Due to the rarity of such metastasis, its clinical features are not well understood. Here, we present the case of a patient with gastric cancer metastasis to the thyroid treated at our hospital.Case Summary: We report the case of a 63-year-old female with a mass in the anterior neck and mild hoarseness for 6 months. The patient underwent proximal subtotal gastrectomy for Siewert III oesophagogastric junction cancer 6 years ago. Subsequently, she received 8 cycles of adjuvant chemotherapy. Her condition was stable until mild hoarseness developed for no apparent reason 6 months prior to presenting at our clinic. Both ultrasonography and computed tomography confirmed a heterogeneous mass in the right lobe of the thyroid gland. Blood thyroid function tests and tumor marker expression levels were normal. Thyroid malignancy was suspected, and the patient underwent a right thyroidectomy. During the surgery, a tumor was found that had invaded the right recurrent laryngeal nerve and trachea. H&E staining and immunohistochemistry results suggested that the cancer cells originated from gastric cancer. The patient was diagnosed with thyroid metastasis of gastric cancer. She refused further treatment and died within 6 months.Conclusion: Metastasis of gastric cancer to the thyroid is rare and is associated with a poor prognosis. Immunohistochemical diagnosis is essential for a conclusive diagnosis. For patients with a history of malignant tumors, the possibility of metastatic thyroid nodules should be ruled out when diagnosing thyroid nodules.

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Signet‐ring cell follicular adenoma of the thyroid

Cited by 3 publications

References 4 publications

Congenital goiter with areas of signet ring cell differentiation in a juvenile giraffe: a very rare entity

Congenital goiter with areas of signet ring cell differentiation in a juvenile giraffe: a very rare entity

Follicular Thyroid Carcinoma with Signet Ring Cell Morphology: Fine-Needle Aspiration Cytology, Histopathology, and Immunohistochemistry

Rare Metastasis of Gastric Cancer to the Thyroid Gland: A Case Report and Review of Literature

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