Esthesioneuroblastoma Metastatic to the Breast in a Young Woman

Mrad, Karima; Mansouri, Dhouha; Driss, Maha; Sassi, Samia; Abbès, Imen; Ayed, Farhat Ben; Romdhane, Khaled Ben

doi:10.1159/000326178

Cited by 11 publications

(10 citation statements)

References 13 publications

(13 reference statements)

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“…Patients with non-Hodgkin lymphoma, melanoma, and carcinoma of the lung, stomach, ovary, kidney and colorectum in adults and children with rhabdomyosarcoma, have a higher risk of metastasis to the breast (5). Table I compares the present rare case of ENB metastasis with two reported cases of ENB metastasis to the breast that have been previously described in the English literature (Table I) (6,7). The patients had an average age of 20.3 years with a range of 13 to 30 years at the first time of diagnosis.…”

Section: Discussionmentioning

confidence: 83%

Esthesioneuroblastoma metastasis to the breast: A case report and review of the literature

et al. 2014

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Metastasis to the breast from an extramammary malignant neoplasm, including esthesioneuroblastoma, is uncommon. The present study describes a rare case of sinonasal esthesioneuroblastoma, Hyams’ histologic grade 2, Kadish’s stage C, T4N0M0, in a 30-year-old female. The patient underwent a radical ethmoidectomy with external beam radiotherapy, followed by chemotherapy including five cycles of cisplatin and etoposide. One year after the initial diagnosis, the patient presented to the hospital with the chief complaint of a rapidly enlarging lump in the right breast. A fine needle aspiration was performed and immunocytochemistry revealed a metastatic esthesioneuroblastoma. The patient received palliative chemotherapy and radiotherapy; however, the patient developed a local recurrence with systemic metastasis and succumbed to the disease seven months later.

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Section: Discussionmentioning

confidence: 83%

Esthesioneuroblastoma metastasis to the breast: A case report and review of the literature

et al. 2014

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“…The sites of distant metastasis reported in various large scale and single case reports are brain, spinal cord, meninges, bone, bone marrow, lung, liver, dermal, breast, heart, parotid and thyroid gland [9][10][11][12][13][14][15][16][17][18][19][20][21] and Table 1. Buohliqa et al [18] have reported three unusual recurrences, distinctly distant from the primary site, raising the questions of what constitutes real recurrence versus embolic metastasis especially around the paranasal sinuses.…”

Section: Discussionmentioning

confidence: 99%

Olfactory Neuroblastoma Presenting as a Submandibular Mass

Appukutty¹

2019

AJLM

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Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.

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“…Все авторы отмечают агрессивность течения этого заболе-вания. Опухоль обладает инфильтративным ростом, проникает в параназальные синусы, орбиту, основание и полость черепа, метастазирует в регионарные лимфа-тические узлы (ЛУ) в 7,8-44,0 % случаев и отдаленные органы -в 3,8-46,0 % [9,10,[14][15][16][17]. ЭНБ диагности-руется на поздней стадии, когда выходит за пределы первичной локализации, у 81,7 %, на ранней стадии -у 18,3 % пациентов [5,[17][18][19][20].…”

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