This work presents a case study of a learning-based approach for target driven map-less navigation. The underlying navigation model is an end-to-end neural network which is trained using a combination of expert demonstrations, imitation learning (IL) and reinforcement learning (RL). While RL and IL suffer from a large sample complexity and the distribution mismatch problem, respectively, we show that leveraging prior expert demonstrations for pre-training can reduce the training time to reach at least the same level of performance compared to plain RL by a factor of 5. We present a thorough evaluation of different combinations of expert demonstrations, different RL algorithms and reward functions, both in simulation and on a real robotic platform. Our results show that the final model outperforms both standalone approaches in the amount of successful navigation tasks. In addition, the RL reward function can be significantly simplified when using pre-training, e.g. by using a sparse reward only. The learned navigation policy is able to generalize to unseen and real-world environments.

Dengue is an acute mosquito-borne infection caused by dengue viruses from the genus flavivirus. Neurologic complications have been attributed chiefly to metabolic alterations and to focal and sometimes massive intracranial haemorrhages, but anecdotal cases and limited case series have indicated the possibility of viral CNS and skeletal muscle invasion causing encephalitis and myositis. We present a case of a 40-year-old male who presented with severe dengue myositis resulting in quadriparesis, respiratory failure and acute renal failure with red urine. His elevated serum creatine kinase (CK), serum and urine myoglobin levels justified rhabdomyolysis as the cause of acute renal failure. A muscle biopsy revealed inflammatory myositis. He required ventilator support for respiratory failure and was treated conservatively. This case highlights the severe and persistent muscle involvement in dengue which is a rarity.

Mirror neurons are one of the most important discoveries in the last decade of neuroscience. These are a variety of visuospatial neurons which indicate fundamentally about human social interaction. Essentially, mirror neurons respond to actions that we observe in others. The interesting part is that mirror neurons fire in the same way when we actually recreate that action ourselves. Apart from imitation, they are responsible for myriad of other sophisticated human behavior and thought processes. Defects in the mirror neuron system are being linked to disorders like autism. This review is a brief introduction to the neurons that shaped our civilization.

Background: Frontline healthcare workers (F-HCWs) are at the forefront of medical care providers against the novel coronavirus 2019 (COVID-19) pandemic which has life-threatening potentials. Inadequate knowledge and incorrect attitudes among HCWs can directly influence practices and lead to delayed diagnosis, poor infection control practices, and spread of disease. Objectives: The aim of this study was to assess the knowledge, attitude and practice (KAP) regarding the COVID-19 pandemic among the frontline healthcare workers (F-HCWs) working at a tertiary care hospital situated in Eastern Uttar Pradesh and to identify the factors significantly associated with KAP. Methods: A cross-sectional study was conducted among 260 health care providers across eastern Uttar Pradesh including Basti city during December 2020. Data was collected using a self-primed pretested questionnaire from the FHCWs working at a tertiary care hospital of eastern Uttar Pradesh. In this survey, a convenience sampling method was adopted. 12 items on knowledge, 10 items on attitude, and 5 items on practices related to COVID-19. The other variables consisted of 4 items on socio-demographic attributes, P-value and 95% confidence intervals (CIs) were performed to assess the attitude and practices in relation to knowledge. Results: Of the total 260 study population, 228 were interviewed online, 32 were self-administered. Knowledge and attitude of the nursing staff were highest but practice score was best for residents. Among different age groups knowledge, attitude and practices scores were highest for 35-45, 45-60 and 25-35 age groups respectively. Respondents having 5-10 years of experience had the best knowledge and the attitude score was highest for HCWs having 10-20 years’ experience but the practice score was higher for HCWs having more than 20 years’ work experience. Overall knowledge score of respondents having strong correlation with attitude (p< 0.05) and to the practice (p<0.05). Conclusion: In this survey many F-HCWs reported adequate overall knowledge with a positive attitude and adopted appropriate practices. The F-HCWs with a higher level of education and more years of experience in health care facilities had better KAP towards COVID-19.

Objective: This study was undertaken as an experimental effort to introduce role-play as a learning tool in teaching of clinical medicine, access its efficacy in understanding clinical scenarios and honing linguistic and examination skills through expression in medical students. The basic hypothesis was that, role-plays can guide the medical students in a better way by gaining knowledge and attitude to deal with real-life situations through simulation acts, so that they can apply this knowledge and skill gained through these simulations in practical examinations, as well as self-application in clinical practice. Methods: This experimental study with a single group pre-and post-test design was carried out in Datta Meghe Institute of Medical Sciences University (NAAC-A) and Jawaharlal Nehru Medical College, Wardha. Twenty-four final year MBBS students were selected for the study. All were subjected to a pre sensitization test in short case format covering affective, cognitive and psychomotor domains from cardiovascular, respiratory, and gastrointestinal system and marks were recorded. Later, the students were sensitized with role-plays of common clinical scenarios and all the role-plays were enacted. Finally, post sensitization test in the same short case format was conducted. Statistical method: student's paired t-test. Results: The post-sensitization scores in each domain were significantly better than the pre-sensitization scores, cognitive domain (95% confidence interval [CI]: −5.14 to −4.60; P < 0.001), affective domain (95% CI −3.26 to −2.65; P < 0.001), and psychomotor domain (955 CI −5.56 to −4.62; P < 0.001), respectively. Conclusion: Role-plays can be used as an extremely effective tool for teaching of clinical medicine.

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Aim: To study Electroencephalogram (EEG) in different stages of chronic kidney disease (CKD). Materials and Methods:This observational study was carried out in the Department of Medicine, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha conducted over a period of 24 months, spanning from August 2011 to August 2013. Eighty three cases of CKD at different stages were studied. EEG was done in all the subjects and the various EEG dynamics like morphometric waveform patterns, symmetricity, amplitude were recorded and compared with the different stages of CKD. Results:We found that characteristic changes were observed with increasing severity of CKD. Slow delta wave patterns were more prominent in stage 5 (p<0.0001), asymmetric discharges, dysthymia, sharp wave transients and low amplitude wave forms were more prominent beyond Stage 4 (p<0.0001).