Dynamics of Electroencephalogram (EEG) in Different Stages of Chronic Kidney Disease

Gadewar, Pradyumna; Acharya, Sourya; Khairkar, Praveen; Shukla, Samarth; Mahajan, Satish

doi:10.7860/jcdr/2015/11257.5705

Cited by 12 publications

(19 citation statements)

References 10 publications

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“…In addition, patients with none to mild frailty in the current study had significantly lower dialysis adequacy (Kt/V) compared to those with moderate to severe frailty (Table 1 ), rendering the former group susceptible to the unfavorable neurologic sequel brought by uremia. Past reports suggested that patients with CKD tend to have more prominent delta wave activities with worsening renal function due to uremic encephalopathy [ 34 ], resulting in the observed increase in delta power among those with mild frailty in the current study. Finally, depression or anxiety reportedly influences delta power in affected patients [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 48%

Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study

et al. 2017

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BackgroundFrailty is prevalent among patients with end-stage renal disease (ESRD) and is associated with an increased risk of cognitive impairment. However, apart from its influence on cognition, it is currently unknown whether frailty affects subtler cerebral function in patients with ESRD.MethodsPatients with ESRD were prospectively enrolled, with clinical features and laboratory data recorded. The severity of frailty among these patients with ESRD was ascertained using the previously validated simple FRAIL scale, and was categorized as none-to-mild and moderate-to-severe frailty. All participants underwent quantitative electroencephalography (EEG), with band powers documented following the generation of the delta to alpha ratio (DAR) and delta/theta to alpha/beta ratio (DTABR). EEG results were then compared between groups of different levels of frailty.ResultsIn this cohort, (mean age: 68.9 ± 10.4 years, 37% male, 3.4 ± 3 years of dialysis), 20, 60, 40, 17, and 6% patients exhibited positivity in the fatigue, resistance, ambulation, illness, and loss-of-body-weight domains, respectively, with 45.7% being none to mildly frail and 54.3% being moderately to severely frail. Those with mild frailty had a significantly higher delta power compared to those with more severe frailty, involving all topographic sites. Patients with ESRD and severe frailty had significantly lower global, left frontal, left temporo-occipital, and right temporo-occipital DAR and DTABR, except in the right frontal area, and tended to have central accentuation of alpha, beta, and theta power, and more homogeneous DTABR and DAR distribution compared to the findings in those with mild frailty.ConclusionsFrailty in patients with ESRD can have subtler neurophysiological influences, presenting as altered EEG findings, which warrant our attention.

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Section: Discussionmentioning

confidence: 48%

Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study

et al. 2017

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“…Six patients (60%) of those who had diffuse slowing ( n = 10) were presented by peripheral polyneuropathy. Gadewar et al ( 32 ) showed that, with progression of CKD stage, frontal sharp wave transients were reported in 71.43% of patients at stage 4 and in 50% of those at stage 5. They found a high theta pattern in both stages.…”

Section: Discussionmentioning

confidence: 99%

Neurophysiological and Neuroradiological Changes in Children With Chronic Kidney Disease

et al. 2020

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Background: Patients with chronic kidney disease (CKD) on maintenance hemodialysis frequently present with neurological complications. These complications include peripheral neuropathy, encephalopathy, and stroke. Objectives: To detect the prevalence of neurological manifestations and complications in children with CKD through neurophysiological and neuro-radiological findings. Methods: The study included 50 patients with CKD admitted to a pediatric nephrology unit. Their history and complete physical and neurological examination findings had been recorded. All patients underwent nerve conduction, electromyography, electroencephalography, and magnetic resonance imaging of the brain. Results: Fifty children of both sexes (23 males and 27 females) with a mean age of (12.08 ± 3.46 year) were studied. Eleven (22%) patients with CKD developed polyneuropathy, mostly of an axonal polyneuropathy pattern, while 39 (78%) of them showed normal electrophysiological studies. No myopathy was detected. Abnormal electroencephalography findings were detected in 18% of patients, mostly generalized and focal (temporal, occipital, and frontal) epileptogenic activity. Abnormal MRI brain findings were detected in 16% of patients, mostly of encephalomalacia. Conclusion: Uremic neuropathy was highly prevalent in children with CKD on maintenance hemodialysis. They developed polyneuropathy, mostly of an axonal polyneuropathy pattern. EEG is a useful method for early recognition of subclinical uremic encephalopathy and/or epileptogenic activity. Early demonstration and management of uremic neurological conditions may decrease the physical disability of CKD patients.

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“…The first EEG recording machine was introduced by Hans Berger in 1929, who suggested that brain currents changed depending upon the functional status of the brain, such as, sleep, anaesthesia, and epilepsy (Siuly et al, 2016). Currently, EEG is expanding beyond sleep, anaesthesia, and epilepsy, and become increasingly important in the diagnosis and treatment of mental and brain neuro-degenerative diseases and abnormalities (Siuly et al, 2016), and other diseases such as chronic kidney disease (Gadewar, 2015), COVID-19 (Petrescu et al, 2020), etc. Recently, it is also used as a neurofeedback method, by means of which the individual may gain better control over the neurophysiological parameters, by inducing changes in brain functioning and, consequently, behavior (Omejc et al, 2019).…”

Section: Electroencephalography (Eeg)mentioning

confidence: 99%

Possibilities of Eeg Diagnostics for Evaluation of the Massage Effects

Ivanova¹,

Alexiev²

2022

Proceeding Book Vol.2

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Massage refers to a wide range of techniques such as effleurage, petrissage, tapping, friction, and vibration, yielding pressure on soft tissues done manually or with devices. Nowadays, massage is widely used in everyday life, sport, and medical care as a complementary and alternative therapy. Although its millenniums of use, there is very little research on its effects on health and disease conditions. As one of the main reasons for this can be pointed out, research methods, most of which need special equipment, and different professionals, are subjective or invasive. Recently, some studies have assessed the physical and physiological effects of massage, such as electroencephalography (EEG). EEG is a rapidly non-invasive test that provides evidence of how the brain functions over time. EEG matured over the decades due to advances in technology. Now it has greater sensitivity, digital recording on hard drives, allowing different processing, and are developed consumer-grade devices, which provide easier obtaining of EEG signals outside of the traditional laboratory settings. Advanced dry wireless headsets enable the use of EEG diagnostic in a natural environment at home, working place, sports halls, fields, etc. EEG has been used for the evaluation of effectiveness and in the comparison between different massage processes. Research investigating the physiological effects of massage therapy with EEG has suggested that massage therapy reduces anxiety, increases frontal delta activity, decreases frontal alpha and beta activity, shifts frontal alpha asymmetry from right-hemisphere dominance to left-hemisphere dominance, increases resting-state alpha activity in the left anterior cingulate cortex, etc. Conclusion: Together, these findings provide evidence that massage therapy acts to modulate EEG activity and that EEG diagnostic can be a useful non-invasive, and accurate, objective research method for investigation and illustration of massage therapy effects.

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Dynamics of Electroencephalogram (EEG) in Different Stages of Chronic Kidney Disease

Cited by 12 publications

References 10 publications

Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study

Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study

Neurophysiological and Neuroradiological Changes in Children With Chronic Kidney Disease

Possibilities of Eeg Diagnostics for Evaluation of the Massage Effects

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