Accuracy of frozen section analysis in correlation with surgical pathology diagnosis

Patil, Parikshit; Shukla, Samarth; Bhake, Arvind; Hiwale, Kishore

doi:10.5455/2320-6012.ijrms20150203

Cited by 19 publications

(32 citation statements)

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“…The diagnostic accuracy of imprint cytology and frozen section were evaluated individually by comparing with the gold standard histopathological examination. The diagnostic accuracy rates of imprint cytology is 80-97 % in different studies [9,[14][15][16][17][18][19][20]. The diagnostic accuracy rates of imprint cytology and frozen section of our study was comparable with that of other studies and we obtained very good results.…”

Section: Discussionsupporting

confidence: 84%

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Role of imprint cytology and frozen section in the diagnosis of tumours

H.V.

et al. 2018

Trop J Pathol Microbiol

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Introduction: Imprint cytology is an economical, simple and quick method with excellent cytological clarity but cannot provide information on the depth of invasion. Frozen section is the standard method of intraoperative diagnosis but is limited by its cost, need of qualified technical staff and the freezing arte facts. Thus, both the techniques have their own limitations and combining these techniques helps in achieving high diagnostic accuracy rates. Aims: 1. To assess the combined role of imprint cytology and frozen section in the diagnosis of tumours of various organs. 2. To compare the diagnostic accuracy of imprint cytology and frozen section individually with that of the histopathological diagnosis. Materials and Methods: The present study was done in the pathology department of Bangalore medical college and research institute for a period of one year. A total of 50 surgical specimens from various organs were studied using imprint cytology and frozen section. The results of both the techniques were compared with the gold standard histopathological diagnosis. Results: Out of 50 cases, majority were ovarian neoplasms comprising of 21 (42%) cases followed by thyroid (14%), breast (12%) and salivary gland (10%) neoplasms. The majority of the cases were malignant (50%) followed by beingn (40%), borderline (6%) and metastatic (4%). The overall diagnostic accuracy of imprint cytology and frozen section in various organs were 94% and 98%respectively. The combined diagnostic accuracy was 98%. Conclusion: Imprint cytology and frozen sections are interdependable intraoperative diagnostic modalities. Imprint cytology alone may not be able to provide a correct diagnosis. Thus, a combination of imprint cytology and frozen section helps in achieving high diagnostic accuracy rates and in distinguishing benign and malignant lesions.

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Section: Discussionsupporting

confidence: 84%

“…Chandrakar J et al, [14] studied 36 breast lesions and imprint cytology correctly diagnosed 30(83.3%) cases and 6 (16.66%) cases were unsatisfactory. In another study by Patil P et al, [19] the diagnostic accuracy of frozen section in breast lesions was 93.75% (15/16 cases).…”

Section: Original Research Articlementioning

confidence: 88%

Role of imprint cytology and frozen section in the diagnosis of tumours

H.V.

et al. 2018

Trop J Pathol Microbiol

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“…The reported specificity of frozen section in literature ranges from 94.55% to 100%. [5][6][7]10 Authors reported the specificity of 97.92%, which is also within the range ( Table 2). Limitations of FS can be divided into three main categories namely sampling error, technical problem and interpretative error.…”

Section: Discussionmentioning

confidence: 55%

“…The overall accuracy of frozen section diagnosis reported in the literature varies from 92% to 97.98%. [4][5][6][7][8][9][10] Present study shows an accuracy rate of 91.57%. This is near the range reported.…”

Section: Discussionmentioning

confidence: 85%

Analysis of frozen section in correlation with surgical pathology diagnosis

2019

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Background: Frozen section (FS) is a rapid diagnostic procedure performed on tissues obtained intraoperatively. This method serves useful purposes, such as determining the malignancy or benignancy of a suspected lesion, determining the adequacy of a biopsy of a suspected lesion, confirming the presence or absence of metastasis, and identifying small structures. But it bears many disadvantages and limitations, the most of which is the danger of incorrect diagnosis. Therefore, it is critical to determine efficiency of frozen section performance periodically. This study was performed to determine accuracy of frozen section by correlating the intra-operative frozen section diagnosis with final diagnosis on permanent sections.Methods: In this retrospective study, authors compared the results of frozen section with their final permanent section diagnosis in Government Medical College and Hospital, Aurangabad, Maharashtra, India during January 2017 to December 2018.Results: Study comprises 83 patients, of which 73 were female and 10 were male. Out of 83 cases, the diagnosis of 76 cases was concordant with conventional histopathology diagnosis while seven were discordant. This gave overall accuracy rate of 91.57% and discordant rate of 8.43%. The overall sensitivity was 85.71% and specificity was 97.92%. The positive predictive and negative predictive value was 96.77% and 90.38% respectively.Conclusions: The accuracy, sensitivity, specificity of frozen section diagnosis in this study are comparable with most international quality control statistics for frozen sections. The results suggest that the correlation of intra-operative frozen section diagnosis with the final histopathological diagnosis on permanent sections forms an integral part of quality assurance activities in the surgical pathology laboratory and specific measures should be taken to reduce the number of discrepancies.

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“…The procedure itself, even in the best hands of the medical laboratory technician, makes the lesion appear worse than a paraffin section of the fixed tissue would. Thus, a good and competent pathologist should know what to expect, what to look for and make a reasonable conclusion without being overtly "clever" [12].…”

Section: Discussionmentioning

confidence: 99%

A study on qualitative comparison between cryostat and conventional technique for histopathology diagnosis

Zinzala

Goswami

et al. 2020

Trop J Pathol Microbiol

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Introduction: Intraoperative consultation by frozen section technique is an invaluable tool for immediate diagnosis. The correlation of intraoperative frozen section diagnosis with final diagnosis on permanent section is an integral part of quality assurance in surgical pathology. Its accuracy and limitations vary with different anatomical sites. Aims & Objective: Qualitative morphological comparison between frozen section and routine formalin fixed paraffin embedded sections in different tissues, to assess the accuracy of frozen section, to detect the number and type of discrepancies and to assess the causes for discrepancies. Material and Method: The present study retrospectively reviewed frozen sections performed in the pathology department, Sirt hospital, government medical college, Bhavnagar during a period of 2 year. Diagnostic accuracy of frozen section and its morphological quality and reliability in comparison to histopathology was evaluated by 2 pathologists in a blinded fashion for the following parameters: cellular outline, nuclear and cytoplasmic features, staining pattern and overall morphology. The results were compared to the routine formalin fixed paraffin sections to evaluate diagnostic accuracy. Discordant cases were reassessed to find the reasons for discrepancy. Result: Diagnostic accuracy of frozen section was 95.1% with false negative case are 4.8% and no false positive case. Statistical analysis showed that most common indications of frozen section in the present study was presence/typing of neoplasm (61.2%) followed by assessment of margin (35.6%) and assessment of nodal status (3.2%). It was observed that nuclear details, cellular outline and overall morphological quality of frozen section was slightly inferior to that of routine histopathology section, however, staining and cytoplasmic details were comparable. The discrepancies were mainly due to technical artefacts (9.7%), sampling error (3.2%) interpretation error (1.6%), and partly due to lack of interdepartmental communication. Conclusion: Frozen section diagnosis is very useful and highly accurate procedure. Gross inspection, sampling by pathologist, frozen complemented with cytological and histological review and intimal cooperation with surgeon can avoid certain limitations and provide rapid, reliable, cost effective information necessary for optimum patient care.

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Accuracy of frozen section analysis in correlation with surgical pathology diagnosis

Cited by 19 publications

References 0 publications

Role of imprint cytology and frozen section in the diagnosis of tumours

Role of imprint cytology and frozen section in the diagnosis of tumours

Analysis of frozen section in correlation with surgical pathology diagnosis

A study on qualitative comparison between cryostat and conventional technique for histopathology diagnosis

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