INTRODUCTIONAcquiring adequate knowledge about drugs and its rational application in clinical practice is considered to be one of the preliminary steps in preparing undergraduate medical students for future practice.1 In this era of knowledge explosion, students often face difficulty in remembering details especially in context to the subject of pharmacology. Though pharmacology forms the backbone of rational therapeutics, unfortunately this subject also bears the academic stigma of being one of the driest and boring subjects. A major attribute to this fact happens to be the traditional way of teaching and learning which focuses more on imparting theoretical knowledge of medicines rather than on using them in actual clinical practice.2,3 So, how do we re-shape our students' attitude towards pharmacology and make them study this subject mindfully and not just mechanically?The answer to this question would be to adopt innovative teaching techniques that promote critical reflective thinking and integration into system-based, organ-based and clinical presentation-based curriculum. This way, students will be challenged to apply these principles to ABSTRACT Background: Pharmacology, a subject criticized by medicos as 'dry and volatile' is in a stage of constant reformation. Traditional teaching-learning in pharmacology has focused more on theoretical knowledge of medicines with little emphasis on the art and science of communicating the same to patients in actual practice. Role-play is one novel method which attracts learners to gain knowledge through concrete experience, there-by bringing in a behavioural change that persists eventually. The objective of this study was to evaluate the effectiveness of role-play as an educational tool in teaching patient education and counseling skills regarding medications prescription for ischemic heart disease (IHD). Methods: A quantitative, randomized, interventional study with pre & post-OSPE using a pre-validated checklist (modified-Calgary-Cambridge) was conducted in 84, II-MBBS students. The scores obtained in intervention group (Lecture-IHD counseling + Role-play) were compared with the control group (Lecture) using Wilcoxon test for paired-data and Mann-Whitney test for intergroup comparisons. Results: Paired-data analysis showed an increase in post-test mean scores in both control and intervention groups following training. However, inter-group comparisons revealed statistically significant improvement in 8 of the 13 parameters in intervention group. Students in intervention group stressed more on pharmacological aspects of medications, along with emergency measures and need for follow-up. Hence it can be said that role-plays played a significant role in improving communication skills regarding medications prescription. Conclusions: Medical communication skills course for II-MBBS students may enable them to demonstrate better patient-doctor interactions. Role-plays are an effective tool to acquire technical and behavioural skills to deal with real-life situations through si...