Background:The "ABO" blood group system is associated with some diseases including gastric and duodenal ulcer, hepatitis B1, vascular diseases, abdominal aortic aneurism, and cancers. Some epidemiological studies demonstrated the linkage among the "ABO" blood group and the risk of type 2 diabetes mellitus (DM). Aims and Objective -This study aimed to find out the possible linkage between "ABO" and "Rhesus" blood groups with type 2 DM. Material and Methods: This study was carried out in Department of Physiology, Muzaffarnagar Medical College and Hospital, Muzaffarnagar from April 2017 to June 2017. This study included total 1316 individuals in which 104 were diabetic patients, and 1212 individuals were non-diabetic apparently healthy controls. Diabetic patients were taken from diabetic outpatient clinics, and the controls were taken from healthy individuals coming for blood donation at blood bank of Muzaffarnagar Medical College and Hospital, Muzaffarnagar. Standard slide agglutination test for the determination of ABO and Rh blood groups was used. Data thus obtained were analyzed by applying Chi-square test to determine any association between DM and different ABO and Rh blood groups. Data were expressed as percent and absolute number of frequency. Results: Increased frequency of blood group AB and blood group O (18.26% vs. 10.31%, 34.61% vs. 29.31%) were found in diabetes. On applying Chi-square test, statistically significant association was found between blood groups AB and O and DM (Chi-square value -8.24, P < 0.04). Increased frequency of Rh positive blood group in diabetic (96.15% vs. 95.54%) but association between Rh blood group and diabetes was not statistically significant. (Chi-square value -0.021, P = 0.88). Conclusion: Blood group might be a risk factor and it can be helpful for the evaluation of the disease.
Background: Benzene exposure is one of the main health concerns for high risk occupations like petrol pump workers. But there is little knowledge about the effect of benzene metabolites on blood parameters. Aims & Objective: The objective of this study is to find out the effect of benzene exposure on hematological parameter especially eosinophil count on petrol pumps workers. Materials and Methods: Fifty four (54) petrol pump workers between age group of 20-60 years were included in this study and categorized into 04 groups according to duration of exposure. The data collected are represented as mean ± SD. These changes were statistically significant (<0.05) when we compared eosinophil count in study group and control group, when duration of exposure is less than 10 years. Results: When we compared eosinophil count in subjects exposed to more than 15 years the count was significantly (<0.05) decreases. The count decreases as the duration of exposure increases. Conclusion: Long term exposure to benzene may cause bone marrow suppression leads to decreased eosinophil count.
Background: Nigella sativa, a widely used medicinal plant throughout the world belongs to family ranunculaceae. Its Seeds and oil have a long history of folklore usage in various traditional systems of medicines and food. This study was performed to evaluate the protective effect of Nigella sativa oil (NSO) on kidney when simultaneously given with colistin sulfate (CS) which induces tubular damage in rats.Methods: Animals were treated for 7 days: Group I (n=6) with normal saline and CMC, Group II, III and IV with 300.000IU/kg/day of CS (n=6). Group III and Group IV with NSO at the dose of 1 and 2ml/kg per orum prior to CS administration. All the animals were sacrificed on 8th day. Afterwards, the plasma creatinine (pCr), blood urea, renal tissue level of malondialdehyde (MDA), reduced glutathione (GSH) and renal histology were performed.Results: Colistin sulfate induced tubular damage, increased the plasma creatinine (pCr), blood urea and MDA levels and decreased the reduced glutathione (GSH). However, simultaneous treatment with Nigella sativa oil at the dose of 1ml/kg and 2ml/kg for one week produced dose dependant improvement in tubular damage and reduced the biochemical alteration.Conclusions: It could be concluded that, Colistin sulfate induced nephrotoxicity is ameliorated by NS oil especially in higher dose of (2ml/kg). This nephroprotective effect is ascribed to free radical scavenging and potent antioxidant activity in Nigella sativa.
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