Eosinophil count in petrol pump workers in and around the Muzaffarnagar City

Abstract

Background: Benzene exposure is one of the main health concerns for high risk occupations like petrol pump workers. But there is little knowledge about the effect of benzene metabolites on blood parameters. Aims & Objective: The objective of this study is to find out the effect of benzene exposure on hematological parameter especially eosinophil count on petrol pumps workers. Materials and Methods: Fifty four (54) petrol pump workers between age group of 20-60 years were included in this study and categorized into 04 groups according to duration of exposure. The data collected are represented as mean ± SD. These changes were statistically significant (<0.05) when we compared eosinophil count in study group and control group, when duration of exposure is less than 10 years. Results: When we compared eosinophil count in subjects exposed to more than 15 years the count was significantly (<0.05) decreases. The count decreases as the duration of exposure increases. Conclusion: Long term exposure to benzene may cause bone marrow suppression leads to decreased eosinophil count.

A Study of Blood Cell Count in Petrol Pump Workers

“…3 Another study conducted by Deepankar singh et al showed that there was significant reduction in eosinophil count with increasing exposure to petroleum fumes. 4 Concerning platelet count, the present study concluded that platelet count was within the normal range. There was no significant difference in platelet count among petrol pump workers and control group.…”

“…Chronic inhalation of petrol fumes may cause toxic effect on haematological, respiratory and neurological systems. 4 Benzene is reported to produce haematological changes ranging from pancytopenia to total bone marrow aplasia through its myelotoxic action. 9 The study group showed that there was significant reduction in RBC count, total leucocyte count and Hb concentration.…”

Efek Hirupan Benzene (C₆H₆) Pada Sel Darah Merah Dan Sel Darah Putih Tikus Putih Jantan (<i>Rattus norvegicus</i>) Strain Wistar

“…Hasil penelitian menunjukan pengaruh yang beragam pada perlakuan pemaparan benzena perinhalasi di evaluasi hapusan darah "tikus putih jantan Rattus norvegicus strain wistar yang dipapar benzena perinhalasi sampai 8 jam/hari 5hari/minggu pada 28 hari. Terjadi penurunan persentase eosinofil dari 0,6% pada kelompok 1 ppm menjadi 0,2% pada kelompok 10 ppm, ini selaras bersama penelitian Singh, et al, 2014 pada 54 petugas pom bensin di Kota Muzaffarnagar, Ia menjelaskan hal ini mungkin disebabkan oleh karena supresi sumsum tulang akibat metabolit benzena [5]. Terjadi peningkatan neutrofil segmen dari 7,6% pada kelompok kontrol menjadi 12,4% pada kelompok 100 ppm, hal ini diduga karena terjadi peningkatan IL8 yang berkolerasi baik dengan peningkatan neutrofil sebagai respon imun bawaan [6].…”