A novel organic nano linker (NL) and manganese metal–organic framework (Mn–MOF) were synthesized and fully characterized. A promising cardiac troponin-I potentiometric biosensor based on Mn–MOF could be used for early myocardial infarction diagnosis.

For the first time, alpha-fetoprotein (AFP) quantification as an early test for liver cancer diagnosis competing with other interfering analytes and factors based on a novel nano-magnetic metal-organic framework (MOF) was investigated. The novel nano-magnetic MOF was synthesized via a simple preparation method, and characterized using various techniques. The X-ray photoelectron spectrum of the nano-magnetic MOF shows Cu 2p, O 1s, N 1s and C 1s peaks that evidence the presence of these elements in the sample without any impurities. Scanning and transmission electron microscopy images show the nano-magnetic MOF with average size between 22 and 43 nm. The results of a photoluminescence study show that the nano-magnetic MOF exhibits strong emission at 418 nm after excitation at 354 nm. Moreover, a Stern-Völmer graph shows a linear calibration curve over an AFP concentration range 1.0-520 ng ml −1 with a correlation coefficient of 0.997, detection limit of 1.18 ng ml −1 and quantitation limit of 3.58 ng ml −1 .According to the marked quenching of the photoluminescence intensity of the nano-magnetic MOF using various concentrations of AFP, it was successfully used as a biosensor for AFP in serum samples collected from hepatitis patients in addition to healthy males and females. The quenching mechanism was well studied, and found to be a dynamic type. The present work offers a simple, low-cost, roomtemperature and rapid technique, being non-time-consuming, highly accurate, selective and highly sensitive compared with most published methods.

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Recently infectious diseases and increasing microbial drug-resistant have caused many humorless health problems. To fill knowledge gaps and guide strategies at all levels for antimicrobials which represent a challenge and an urgent need. For these reasons, our target is developing a new effective antimicrobial drug with extended action time, multi-antimicrobial agents, low toxicity, and safe strategies. Metal–organic frameworks are promising materials for antimicrobial agents. Herein, a novel affordable Fe(III)-MOF was simply prepared via a reflux method. FE-SEM images showed an octahedral structure with sharp edges with high crystallinity and purity of Fe(III)-MOF. Under optimum conditions, the Fe(III)-MOF showed excellent antimicrobial efficiency against ± bacteria, fungus, and yeast with an inhibition zone ranging between 40–46 and 22–24 mm at a concentration of 50 and 25 μg/mL Fe(III)-MOF, respectively. As well, the mechanism of interaction is also well studied. The results open the door for the use of prepared materials as an effective and efficient antimicrobial agent. Graphical abstract

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