A novel Iron(III)-based MOF: Synthesis, characterization, biological, and antimicrobial activity study

Abstract

Recently infectious diseases and increasing microbial drug-resistant have caused many humorless health problems. To fill knowledge gaps and guide strategies at all levels for antimicrobials which represent a challenge and an urgent need. For these reasons, our target is developing a new effective antimicrobial drug with extended action time, multi-antimicrobial agents, low toxicity, and safe strategies. Metal–organic frameworks are promising materials for antimicrobial agents. Herein, a novel affordable Fe(III)-MOF was simply prepared via a reflux method. FE-SEM images showed an octahedral structure with sharp edges with high crystallinity and purity of Fe(III)-MOF. Under optimum conditions, the Fe(III)-MOF showed excellent antimicrobial efficiency against ± bacteria, fungus, and yeast with an inhibition zone ranging between 40–46 and 22–24 mm at a concentration of 50 and 25 μg/mL Fe(III)-MOF, respectively. As well, the mechanism of interaction is also well studied. The results open the door for the use of prepared materials as an effective and efficient antimicrobial agent. Graphical abstract

Structural Study, Spectroscopic Characterization and Evaluation of the Antimicrobial Behavior of a New Fe (III) Organic‐Inorganic Hybrid Material: (C8H14N2)4[(FeCl6)(FeCl4)]Cl4

“…In addition, the antibacterial action of the ferric complex could also be related to the release of free ions in the solution that facilitates interaction between metal ions and bond. [56][57][58] Based on the strongest effect of the complex against gram positive bacteria as compared to gram negative bacteria, we suggest that our complex can affect the cell wall integrity of the microbial cell. This investigation was confirmed by the significant lysozyme activity against both gram positive cell wall from Micrococcus luteus and Staphylococcus aureus, with 27.99 UA/ml/min and 8.26 UA/ml/min, respectively.…”

Metal-Organic Frameworks: Versatile Platforms for Biomedical Innovations

“…Their discovery showed that the rough surface of the MOF facilitated the efficient loading and release of primary fibroblast growth factors, promoting angiogenesis and collagen deposition. Bacterial infections, another challenging area of biomedicine, where studying metal-organic compounds begins to take a broader profile, were also partly addressed by Sheta et al [ 81 ]. Their research highlighted the ability of Fe(III)-MOF to inhibit the growth of bacteria, fungi, and yeasts, with excellent antimicrobial efficacy, at a concentration of 50 and 25 μg/mL Fe(III)-MOF.…”

Application and Development Prospect of Nanoscale Iron Based Metal-Organic Frameworks in Biomedicine

“… 43 As indicated by the above analysis, Fe-MOFs molecule exhibit high antibacterial activity against microorganisms, fungus, and yeast, as shown in Figure 13A and B . 162 , 163 MOFs containing bioactive links: For instance, it is obtained through the self-assembly of Fe 3+ ion and doxorubicin hydrochloride (DOX) molecule Fe-DOX@Gd-MOF, showing higher stability and controllable DOX release, as shown in Figure 13C . 139 Nevertheless, there has been scarce research in this category.…”

“…Creative Commons. 163 ( C ) Synthesis of a mesoporous MIL-100(Fe) bacteria exoskeleton Reprinted from Permyakova A, Kakar A, Bachir J, et al In Situ Synthesis of a Mesoporous MIL-100(Fe) Bacteria Exoskeleton. ACS Materials Lett .…”