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A study about an emerging approach to enhance the biological properties by incorporating nanoparticles within the hydrogel networks using citric acid, diethyleneglycol, and indole-3-acetic acid a three component hydrogels prepared by polycondensation. A stable and uniformly distributed silver and gold nanoparticles have been introduced successfully in hydrogel network resulted in nanocomposite hydrogels. The surface morphology of silver and gold hydrogel have been compared using scanning electron microscope with energy dispersive X-ray spectroscopy analysis and transmission electron microscopy techniques and thermal stability was studied by thermogravimetric analysis. The swelling studies have also been carried out for nanocomposite hydrogels at various pH solution. The nanocomposite hydrogels have exhibited antibacterial activity and nontoxic nature confirmed by the cytotoxicity effect. The results of the study indicated that the nanocomposite hydrogels may be recommended for wound healing applications. Comparatively, silver nanocomposite hydrogel was better performance than gold nanocomposite hydrogel. POLYM. ENG. SCI., 00:000-000,

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Gold nanoparticles (AuNPs) are widely used and important nanomaterials and combine with hydrogels to design novel nanocomposite hydrogels. An emerging approach to strengthen the polymeric hydrogels and to include multiple functionalities focuses on incorporating nanoparticles within the hydrogel network. This present investigation focused on the most recent developments in the field of nanocomposite hydrogels with emphasis on biomedical applications. The pH-responsive nanocomposite hydrogels based on indole-3-acetic acid (IAA), which has extracted from leaf of Stachytarpheta jamaicensis, citric acid, diethylene glycol and colloidal gold nanoparticles. The obtained nanocomposite hydrogels found to have desired surface morphology and enhanced pH-sensitive swelling and thermal stability. The resultant nanocomposite hydrogels may be recommended for biomedical applications mere in future such as pH-sensitive drug delivery, wound healing application, anti cancer, antimicrobial material, antioxidant, cytotoxicity with more than 80% cell viability and nanomedicine.

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