pH-sensitive biopolymeric hydrogel-based on indole-3-acetic acid for wound healing and anti-cancer applications

Abstract

Gold nanoparticles (AuNPs) are widely used and important nanomaterials and combine with hydrogels to design novel nanocomposite hydrogels. An emerging approach to strengthen the polymeric hydrogels and to include multiple functionalities focuses on incorporating nanoparticles within the hydrogel network. This present investigation focused on the most recent developments in the field of nanocomposite hydrogels with emphasis on biomedical applications. The pH-responsive nanocomposite hydrogels based on indole-3-acetic acid (IAA), which has extracted from leaf of Stachytarpheta jamaicensis, citric acid, diethylene glycol and colloidal gold nanoparticles. The obtained nanocomposite hydrogels found to have desired surface morphology and enhanced pH-sensitive swelling and thermal stability. The resultant nanocomposite hydrogels may be recommended for biomedical applications mere in future such as pH-sensitive drug delivery, wound healing application, anti cancer, antimicrobial material, antioxidant, cytotoxicity with more than 80% cell viability and nanomedicine.

Assessment of the Anti-Inflammatory, Antibacterial and Anti-Aging Properties and Possible Use on the Skin of Hydrogels Containing Epilobium angustifolium L. Extracts

“…According to ISO 10993-5:2009 "Biological evaluation of medical devices" substances are biocompatible if they do not diminish cell viability below 75% (Chitra et al, 2019). Therefore in the current study, regardless of the extraction method (and viability assay), hydrogels containing 5-100 μg/ml of the EA extracts may be considered non-toxic and appropriate for biomedical applications.…”

pH-Sensitive Biomaterials for Drug Delivery

“…Currently, the use of pH-sensitive hydrogels for cancer therapy has been investigated as improving the efficiency of the released drugs [114][115][116][117][118]. Polymers commonly used to study pH-responsive hydrogels including polyacrylate, poly (N-isopropyl acrylamide), polyacrylate, n-vinyl caprolactam, sodium alginate, and carrageenan [119,120].…”

Recent Progress in Gold‐Catalyzed Reactions of Alkynes for the Construction of Indole Frameworks

“…[22] Beyond the diverse bioactivities, indole compounds deserve practical importance in the field of materials sciences, viz, organic light emitting diodes (OLEDs) [23][24][25] and biopolymers. [26][27] They are frequently applied in dye-sensitized solar cells. [28][29][30] Fluorescent probes bearing indole subunit have effectively been employed for the detection of specific ions.…”

“…Beyond the diverse bioactivities, indole compounds deserve practical importance in the field of materials sciences, viz, organic light emitting diodes (OLEDs) [23–25] and biopolymers [26–27] . They are frequently applied in dye‐sensitized solar cells [28–30] .…”