Non toxic, antibacterial, biodegradable hydrogels with pH-stimuli sensitivity: Investigation of swelling parameters

Sudarsan, S.; Franklin, David S.; Sakthivel, M.; Guhanathan, S.

doi:10.1016/j.carbpol.2016.04.060

Cited by 48 publications

(16 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the robust discovery of Hydroxyethyl Methacrylate (HEMA) hydrogels in 1960, they have been extensively utilized for biomedical applications [15] . Multifarious hydrogels currently in use for a wide range of diseases include but not limited to stimuli sensitive hydrogels [16][17][18][19][20][21][22][23][24][25][26][27][28][29] , redox-active injectable hydrogels [30][31][32][33][34] .…”

Section: Hydrogelsmentioning

confidence: 99%

Liver trauma: An Insight into Therapeutic Approach

Obulesu¹,

Internationals²

2016

JNMS

View full text Add to dashboard Cite

Therapeutic Avenues for Livery Trauma Diagnosing the extent of liver trauma and understanding the severity play a key role in employing appropriate treatment strategies. Patients with severe hepatic trauma involving hemodynamic instability require surgical intervention. Novel therapeutic avenues such as hepatic artery embolization and liver transplantation have been extensively used in the treatment of extremely severe hepatic damage currently [4]. Although angioembolization procedure shows the success rate of 93%, a few associated complications such as hepatic necrosis (15%), abscess formation (7.5%), and bile leaks limit its success [5]. In another study, studies on wistar rats showed that the collagen adhesive associated with fibrinogen and thrombin successfully attenuates experimental hepatic injury by curtailing the occurrence of adhesions between the liver and the surrounding structures [6]. Recently, in vitro and in vivo studies showed that betaine which is an ingredient in food and also synthesized in liver, plays a pivotal role in reversing the liver injury significantly [7]. Absorbable mesh-wrapping has been used to overcome the liver trauma [8]. Remarkably reduced incidence of septic complications and absence of re-bleeding hazard are a few advantages associated with this treatment. Growing lines of evidence sug

show abstract

Section: Hydrogelsmentioning

confidence: 99%

Liver trauma: An Insight into Therapeutic Approach

Obulesu¹,

Internationals²

2016

JNMS

View full text Add to dashboard Cite

show abstract

“…Hydrogel structures composed of synthetic polymers, namely, acrylamide (AAm) and acrylic acid (AAc), are more commonly used as superabsorbent materials . Superabsorbent hydrogels based on natural polymers, such as chitosan, starch, collagen, cellulose, sodium alginate, and guar gum, have drawn much attention because of their nontoxic behavior, elevated hydrophilic nature, and promising biodegradability . Hydrogels with enhanced properties that can respond to changes in their environment and thus act as smart or intelligent materials enable them to be used in a more user‐friendly way …”

Section: Introductionmentioning

confidence: 99%

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels for in vitro controlled release of vitamin B₁₂

Nath¹,

Chowdhury²,

Ali³

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

Gelatin (Ge)‐g‐poly(acrylic acid‐co‐acrylamide) and montmorillonite (MMT)‐clay‐based nanocomposite hydrogels were fabricated to study the controlled release of vitamin B12. Polymeric hydrogels were characterized with Fourier transform infrared (FTIR) spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). FTIR spectroscopy confirmed the grafting of partially neutralized acrylic acid on a Ge backbone. The incorporation of MMT fillers inside the nanocomposite hydrogels and their increased crystallinity were established by XRD analysis. The rough surface morphologies of the composite hydrogels shown by SEM resulted from the assimilation of MMT inside the same. TEM confirmed the formation of nanosized composites. The average length and width of the MMT platelets were found to be 184.37 and 20.48 nm, respectively. The maximum swelling of the hydrogel was 375 g/g, and the results were established with Design‐Expert software. The biodegradability of the nanocomposite increased in comparison to that of the copolymer hydrogel. Biocompatibility and cytotoxicity studies were also performed. During different time intervals, the controlled release of vitamin B12 in artificial gastric fluid (AGF) and artificial intestinal fluid (AIF) was evaluated with a UV–visible spectrophotometer; this resulted in different controlled release curves. The release in AGF was 42%, and in AIF, the cumulative release was 80% over 6 h. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47596.

show abstract

“…Figure 1 shows the monomers constituting the alginate polymer. Alginate is easily bonded to most divalent cations, such as Ca 2+ , Ba 2+ , and Cu 2+ , to form an ion cross-linked alginate hydrogel [10], which is metabolized into monomers of mannose and glucuronic acid by enzymatic hydrolysis in vivo that are nontoxic to humans [11]. In addition, alginate has the advantages of no immunogenicity and a certain biological sustained release [12].…”

Section: Introductionmentioning

confidence: 99%

The Investigation of LRP5-Loaded Composite with Sustained Release Behavior and Its Application in Bone Repair

Jiang

et al. 2019

International Journal of Polymer Science

View full text Add to dashboard Cite

Low-density lipoprotein receptor-related protein 5 (LRP5) plays a vital role in bone formation and regeneration. In this study, we developed an injectable and sustained-release composite loading LRP5 which could gelatinize in situ. The sustained release of the composite and its efficacy in bone regeneration were evaluated. Sodium alginate, collagen, hydroxyapatite, and LRP5 formed the composite LRP5-Alg/Col/HA. It was found that the initial setting time and final setting time of LRP5-Alg/Col/HA containing 4% alginate were suitable for surgical operation. When the composite was loaded with 40 μg/mL LRP5, LRP5-Alg/Col/HA did not exhibit a burst-release behavior and could sustainably release LRP5 up to 21 days. Up to 18 days, LRP5 released from LRP5-Alg/Col/HA still present the binding activity with DKK1 (Wnt signaling pathway antagonist) and could increase the downstream β-catenin mRNA in bone marrow mesenchymal stem cells. Moreover, LRP5-Alg/Col/HA was found to significantly increase bone mineral density in the defect area after 6 weeks’ implantation of LRP5-Alg/Col/HA into the rats’ calvarial defect area. H&E staining detection demonstrated that LRP5-Alg/Col/HA could mediate the formation of a new bone tissue. Therefore, we concluded that Alg/Col/HA was a suitable sustained-release carrier for LRP5 and LRP5-Alg/Col/HA had a significant effect on repairing bone defects and could be a good bone regeneration material.

show abstract

Non toxic, antibacterial, biodegradable hydrogels with pH-stimuli sensitivity: Investigation of swelling parameters

Cited by 48 publications

References 44 publications

Liver trauma: An Insight into Therapeutic Approach

Liver trauma: An Insight into Therapeutic Approach

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels for in vitro controlled release of vitamin B₁₂

The Investigation of LRP5-Loaded Composite with Sustained Release Behavior and Its Application in Bone Repair

Contact Info

Product

Resources

About

Non toxic, antibacterial, biodegradable hydrogels with pH-stimuli sensitivity: Investigation of swelling parameters

Cited by 48 publications

References 44 publications

Liver trauma: An Insight into Therapeutic Approach

Liver trauma: An Insight into Therapeutic Approach

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels for in vitro controlled release of vitamin B12

The Investigation of LRP5-Loaded Composite with Sustained Release Behavior and Its Application in Bone Repair

Contact Info

Product

Resources

About

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels for in vitro controlled release of vitamin B₁₂