Liver trauma: An Insight into Therapeutic Approach

Abstract

Therapeutic Avenues for Livery Trauma Diagnosing the extent of liver trauma and understanding the severity play a key role in employing appropriate treatment strategies. Patients with severe hepatic trauma involving hemodynamic instability require surgical intervention. Novel therapeutic avenues such as hepatic artery embolization and liver transplantation have been extensively used in the treatment of extremely severe hepatic damage currently [4]. Although angioembolization procedure shows the success rate of 93%, a few associated complications such as hepatic necrosis (15%), abscess formation (7.5%), and bile leaks limit its success [5]. In another study, studies on wistar rats showed that the collagen adhesive associated with fibrinogen and thrombin successfully attenuates experimental hepatic injury by curtailing the occurrence of adhesions between the liver and the surrounding structures [6]. Recently, in vitro and in vivo studies showed that betaine which is an ingredient in food and also synthesized in liver, plays a pivotal role in reversing the liver injury significantly [7]. Absorbable mesh-wrapping has been used to overcome the liver trauma [8]. Remarkably reduced incidence of septic complications and absence of re-bleeding hazard are a few advantages associated with this treatment. Growing lines of evidence sug