Noncytotoxic silver and gold nanocomposite hydrogels with enhanced antibacterial and wound healing applications

Abstract

A study about an emerging approach to enhance the biological properties by incorporating nanoparticles within the hydrogel networks using citric acid, diethyleneglycol, and indole-3-acetic acid a three component hydrogels prepared by polycondensation. A stable and uniformly distributed silver and gold nanoparticles have been introduced successfully in hydrogel network resulted in nanocomposite hydrogels. The surface morphology of silver and gold hydrogel have been compared using scanning electron microscope with energy dispersive X-ray spectroscopy analysis and transmission electron microscopy techniques and thermal stability was studied by thermogravimetric analysis. The swelling studies have also been carried out for nanocomposite hydrogels at various pH solution. The nanocomposite hydrogels have exhibited antibacterial activity and nontoxic nature confirmed by the cytotoxicity effect. The results of the study indicated that the nanocomposite hydrogels may be recommended for wound healing applications. Comparatively, silver nanocomposite hydrogel was better performance than gold nanocomposite hydrogel. POLYM. ENG. SCI., 00:000-000,

A comprehensive review of the polymer‐based hydrogels with electrochemically synthesized silver nanoparticles for wound dressing applications

“…The production of the hydrogel can be achieved via different methods, and chitosan is most frequently applied as a blend, or a copolymer with different polymeric materials, such as gelatin, [87][88][89] dextran, 90 alginate, 91,92 hyaluronic acid, 93 polyacrylamide, 94 or PVA 36,95,96 ; however, some studies report free-standing AgNP-containing pure chitosan hydrogels. [97][98][99][100] The versatility of possible AgNPs syntheses routes is also impressive, with the most common methods including chemical synthesis using either trisodium citrate, 97,101,102 ascorbic acid, 103,104 or sodium tetrahydridoborate 87,95,105 as a reducing agent, but also biosynthesis using natural extracts such as hyacinth plant leaves, 106 Combretum erythrophyllum, 107 Crinum latifolium, 108 Curcuma longa, 94 Fusarium verticillioides, 99 or Sanghuangporus sanghuang. 109 On the other hand, a frequently-applied route to obtain silver nanoparticles is simply mixing in a precursor (such as silver nitrate) into the polymer solution where simultaneous reduction of Ag + , formation of AgNPs and their stabilization takes place, 92,93,[110][111][112] due to the well-known ability of chitosan to reduce silver and to form a hydrogel with AgNPs at the same time.…”

Poly(acrylic acid) hydrogel microparticles fabricated with silver nanoparticles: synthesis, characterization, and catalytic applications

“…The properties of metals change when metals are designed in nano size domain. [ 1‐2 ] Nobel metals such as gold, silver and platinum have been observed as very efficient catalysts when they are in their nano size form. [ 3‐4 ] Owing to comparatively low cost of silver and its substantial catalytic efficacy, nano sized silver has become the subject of high demand.…”

An inorganic cross‐linked quadruple shape memory hydrogel with high mechanical performance

“…Hydrogel is a kind of hydrophilic three-dimensional network polymer whose internal network is cross-linked by physical or chemical methods. With the development of researches on hydrogels, hydrogels are gradually extended to cartilage scaffolds, [1] strain sensors, [2][3][4] tissue-engineered skin scaffolds, [5] medicine, [6,7] soft tissue filling, [8] and smart materials. [9][10][11] As an important component of intelligent hydrogels, shape memory hydrogels (SMHs) can respond to external stimulus.…”