Investigation on pH/salt-responsive multifunctional itaconic acid based polymeric biocompatible, antimicrobial and biodegradable hydrogels

Sakthivel, M.; Franklin, David S.; Sudarsan, S.; Chitra, G.; Sridharan, T. B.; Guhanathan, S.

doi:10.1016/j.reactfunctpolym.2017.10.021

Cited by 32 publications

(16 citation statements)

References 75 publications

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“…The PVA + Ia film containing TBE registered a MIC of 2.5 mg DW/mL, and the PVA + Ia without TBE registered a MIC of 5 mg DW/mL against P. aeruginosa; therefore, both had no antibacterial effect. This fact could be explained by the low concentration of Ia used, precisely 1%, insufficient to exert its previously reported antimicrobial characteristics [66,67]. Both the inherent antibacterial characteristics and film forming capacity of Ch make it the best candidate for use as an active packaging material [68,69].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

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Active Packaging—Poly(Vinyl Alcohol) Films Enriched with Tomato By-Products Extract

et al. 2020

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Active films were prepared from poly(vinyl alcohol) (PVA) blended with itaconic acid (Ia), and with chitosan (Ch), enriched with tomato processing by-products extract (TBE) in order to develop new bioactive formulations for food packaging. The effects of two biopolymers (Ch, Ia) and of the incorporated TBE—containing phenolic compounds and carotenoids—were studied regarding the physical and antimicrobial properties of films; in addition, their influence on the total phenolic content, viscosity, and flow behavior on the film-forming solutions was investigated. The results showed increased physical properties (diameter, thickness, density, weight) of the films containing the TBE versus their control. TBE and Ch conferred significant antimicrobial effects to PVA films toward all the tested microorganisms, whereas the best inhibition was registered against S. aureus and P. aeruginosa, with a minimum inhibitory concentration of <0.078 mg DW/mL. The Ia-PVA films also exhibited some antibacterial activity against P. aeruginosa (2.5 mg DW/mL). The total phenolic content of the film-forming solutions presented the highest values for the TBE and Ch-added PVA samples (0.208 mg gallic acid/100 mL film-forming solution). These results suggest that the PVA + Ch film containing TBE can be used for the development of intelligent and active food packaging materials.

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Section: Antimicrobial Activitymentioning

confidence: 99%

“…characteristics [66,67]. Both the inherent antibacterial characteristics and film forming capacity of Ch make it the best candidate for use as an active packaging material [68,69].…”

Section: Physical Characterization Of Solid Filmsmentioning

confidence: 99%

Active Packaging—Poly(Vinyl Alcohol) Films Enriched with Tomato By-Products Extract

et al. 2020

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“…A wide variety of microorganisms like fungi, bacteria, protozoa acted on the hydrogels under aerobic degradation. After degradation, H 2 O, CH 4 , CO 2 and other compounds were produced [160].…”

Section: Major Applications Of Iamentioning

confidence: 99%

Biomass-Derived Production of Itaconic Acid as a Building Block in Specialty Polymers

Teleky

Vodnar

2019

Polymers

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Biomass, the only source of renewable organic carbon on Earth, offers an efficient substrate for bio-based organic acid production as an alternative to the leading petrochemical industry based on non-renewable resources. Itaconic acid (IA) is one of the most important organic acids that can be obtained from lignocellulose biomass. IA, a 5-C dicarboxylic acid, is a promising platform chemical with extensive applications; therefore, it is included in the top 12 building block chemicals by the US Department of Energy. Biotechnologically, IA production can take place through fermentation with fungi like Aspergillus terreus and Ustilago maydis strains or with metabolically engineered bacteria like Escherichia coli and Corynebacterium glutamicum. Bio-based IA represents a feasible substitute for petrochemically produced acrylic acid, paints, varnishes, biodegradable polymers, and other different organic compounds. IA and its derivatives, due to their trifunctional structure, support the synthesis of a wide range of innovative polymers through crosslinking, with applications in special hydrogels for water decontamination, targeted drug delivery (especially in cancer treatment), smart nanohydrogels in food applications, coatings, and elastomers. The present review summarizes the latest research regarding major IA production pathways, metabolic engineering procedures, and the synthesis and applications of novel polymeric materials.

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“…Antimicrobial inhibition is very crucial especially in biomedical applications. Infections may cause biomaterial failure in wound dressings, drug release systems, and pharmaceutical applications [32]. Among the antimicrobial agents, metal nanoparticles are one of the most promising agents in terms of physical, chemical, and biological features.…”

Section: Introductionmentioning

confidence: 99%

Electrospun nanofibers of poly (acrylonitrile-co-itaconic acid)/silver and polyacrylonitrile/silver: In situ preparation, characterization, and antimicrobial activity

Baskan

Esentürk²,

Döşler

et al. 2019

Journal of Industrial Textiles

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In this study, it was aimed to prepare silver nanoparticles by reduction of silver salt (AgNO3) in situ by means of only synthesized polyacrylonitrile (PAN) and poly(acrylonitrile-co-itaconic acid) (P(AN-co-IA)) polymers, and N,N dimethylformamide (DMF). Thereafter, PAN/Ag and P(AN-co-IA)/Ag nanofibers were prepared via electrospinning. Spectroscopic and morphologic characterizations, electrical and thermal features, and antimicrobial activities of the prepared nanofibers against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans were carried out in detail. It was observed that P(AN-co-IA) was much more effective than PAN on the reduction of AgNO3 and formation of silver nanoparticles. Silver nanoparticles and also itaconic acid contributed to decrease the cyclization temperature of PAN by generating sharp exothermic peaks. In addition, electrical conductivity of the nanofibers increased dramatically from E−13 to E−4 related to the presence of silver nanoparticles. Furthermore, incorporation of silver nanoparticles to the nanofiber membranes let bactericidal/fungicidal activities, which started at 6–24 h and continued for up to 168 h, against S. aureus, E. coli, P. aeruginosa, and C. albicans. The prepared silver containing nanofibers can be regarded as good candidates for potential use in the biomedical and pharmaceutical applications.

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Investigation on pH/salt-responsive multifunctional itaconic acid based polymeric biocompatible, antimicrobial and biodegradable hydrogels

Cited by 32 publications

References 75 publications

Active Packaging—Poly(Vinyl Alcohol) Films Enriched with Tomato By-Products Extract

Active Packaging—Poly(Vinyl Alcohol) Films Enriched with Tomato By-Products Extract

Biomass-Derived Production of Itaconic Acid as a Building Block in Specialty Polymers

Electrospun nanofibers of poly (acrylonitrile-co-itaconic acid)/silver and polyacrylonitrile/silver: In situ preparation, characterization, and antimicrobial activity

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