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Our results suggest an association between reduced exercise capacity, low HRQoL and increases in depressive symptoms in clinically stable asthmatic subjects. These results suggest the need to assess physical fitness and psychosocial distress during asthma treatment and the importance of a multidisciplinary approach.

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The aim of this study is to compare the effects of aerobic conditioning (AC) before (ACBS) and after (ACAS) allergic sensitization. BALB/c mice were divided into two main groups: ACBS and ACAS. Each groups was divided into subgroups: control (nonsensitized/nontrained), AC (nonsensitized/trained), ovalbumin (OVA) (sensitized/nontrained), AC+OVA (trained/sensitized), and OVA+AC (sensitized/trained). Sensitization was induced using OVA and AC performed in treadmill (moderate intensity). We examined IgE and IgG1 levels, eosinophil counting, expression of Th1 (interleukin (IL)-2, IFN-α) and Th2 cytokines (IL-4, IL-5, IL-13), IL-10, vascular endothelial growth factor (VEGF), and airway remodeling. IgE and IgG1 were decreased only when exercise was performed before sensitization (ACBS); however, there was a decrease of eosinophils, Th2 cytokines, VEGF, and airway remodeling and increase in IL-10 in either ACBS or ACAS groups. Our results demonstrate that aerobic conditioning reduces Th2 response before and after sensitization by increasing IL-10 while the production of anaphylactic antibodies is reduced only when exercise is performed before sensitization.

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Despite the number of practitioners it seems that there are few athletes in Brazil with expressive results internationally. Objective: Compare the performance of the Brazilian elite runners in the marathons around of the world. Methods: A retrospective study comparing the time and positions of the Brazilian founders with the main athletes in the world in the 12 main marathons of the world, from 2016 to 2018. Results: Data show that the number of street marathon runners increases in Brazil each year, but our elite marathoners have not achieved lower times (p<0.001), positions far from the main African athletes and poor performance in the majors, worldwide and Olympic Games. Conclusion: Despite physical training, the performance of Brazilian marathoners is not enough to compete with Kenyan athletes and Ethiopians due to the genetic superiority, and physiology, and biomechanics features of Africans. This distance seems to occur due to differences in the metabolic and biomechanical mechanisms that make the running economy of these African marathoners more efficient, so they are almost unbeatable in marathons, because the modality requires a lot of resistance and great cardiorespiratory capacity.

<p>A asma é uma doença inflamatória crônica das vias aéreas cujo diagnóstico é clínico e o tratamento visa principalmente controlar os sintomas e diminuir os riscos de exacerbação. Mesmo sob tratamento clínico-medicamentoso adequado, os pacientes nem sempre atingem o controle clínico adequado. Por isso, recomenda-se o uso de terapias não farmacológicas, destacando-se o exercício físico (EF), que é, atualmente, reconhecido como parte fundamental do programa de reabilitação para asmáticos. A revisão que se segue objetivou explorar os aspectos relacionados à melhora do controle clínico da doença induzidos pelo EF em pacientes asmáticos. Para tanto, foram revisados artigos publicados na base de dados Pubmed e SciELO (de 1970 a 2015). Verificou-se que os primeiros estudos sugeririam que o EF, predominantemente aeróbio, melhora o condicionamento físico e a percepção de falta de ar (dispneia). Essa tendência foi mantida até os anos 90 e a partir de então surgiram estudos com maior rigor metodológico mostrando que o EF pode reduzir o broncoespasmo induzido pelo exercício (BIE), a responsividade brônquica bem como e a capacidade física aeróbia. Evidências mostrando que o EF melhora os fatores de saúde relacionados à qualidade de vida, o controle clínico da asma e a inflamação pulmonar passaram a ser melhor investigados apenas nos últimos 5 anos. Atualmente, considera-se a prática de EF como um componente fundamental no programa de tratamento para pacientes com asma moderada e grave, quando realizado com predominância aeróbia, em intensidade de baixa a moderada e feito pelo menos duas vezes por semana de forma individualizada. Portanto, o exercício físico parece potencializar o controle clínico da asma através da melhora do condicionamento físico, sendo importante sua indicação na prática clínica para os pacientes que estão em tratamento clínico-medicamentoso otimizado.</p>