Association between Maximal Aerobic Capacity and Psychosocial Factors in Adults With Moderate-to-Severe Asthma

Mendes, Felipe; Lunardi, Adriana Cláudia; Silva, Ronaldo Aparecido da; Cukier, Alberto; Stelmach, Rafaël; Martins, Mílton A.; Carvalho, Celso Ricardo Fernandes

doi:10.3109/02770903.2013.786724

Cited by 18 publications

(10 citation statements)

References 30 publications

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“…Asthmatic exercisers have a lower bronchoconstriction, even though they were without a therapy to eliminate the hyperresponsiveness of the airways. Additionally, physical exercise improves aerobic capacity and the endurance of respiratory muscles, making asthma attacks less uncomfortable (2, 5). …”

Section: Introductionmentioning

confidence: 99%

Intensity of swimming exercise influences tracheal reactivity in rats

Brito

Silva

Souza

et al. 2015

J. Smooth Muscle Res.

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Studies that evaluate the mechanisms for increased airway responsiveness are very sparse, although there are reports of exercise-induced bronchospasm. Therefore, we have evaluated the tracheal reactivity and the rate of lipid peroxidation after different intensities of swimming exercise in rats. Thus, male Wistar rats (age 8 weeks; 250–300 g) underwent a forced swimming exercise for 1 h whilst carrying attached loads of 3, 4, 5, 6 and 8% of their body weight (groups G3, G4, G5, G6 and G8, respectively; n=5 each). Immediately after the test, the trachea of each rat was removed and suspended in an organ bath to evaluate contractile and relaxant responses. The rate of lipid peroxidation was estimated by measuring malondialdehyde levels. According to a one-way ANOVA, all trained groups showed a significant decrease in the relaxation induced by aminophylline (10−12–10−1 M) (pD2=3.1, 3.2, 3.3, 3.3 and 3.2, respectively for G3, G4, G5, G6 and G8) compared to the control group (pD2=4.6) and the Emax values of G5, G6, G8 groups were reduced by 94.2, 88.0 and 77.0%, respectively. Additionally, all trained groups showed a significant increase in contraction induced by carbachol (10−9–10−3 M) (pD2=6.0, 6.5, 6.5, 7.2 and 7.3, respectively for G3, G4, G5, G6 and G8) compared to the control group (pD2=5.7). Lipid peroxidation levels of G3, G4 and G5 were similar in both the trachea and lung, however G6 and G8 presented an increased peroxidation in the trachea. In conclusion, a single bout of swimming exercise acutely altered tracheal responsiveness in an intensity-related manner and the elevation in lipid peroxidation indicates a degree of oxidative stress involvement.

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Section: Introductionmentioning

confidence: 99%

Intensity of swimming exercise influences tracheal reactivity in rats

Brito

Silva

Souza

et al. 2015

J. Smooth Muscle Res.

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“…However, no studies have examined the effect of emotional and affective factors on exertional dyspnoea during exercise. In a study of moderate-to-severe Brazilian asthma subjects by MENDES et al [63], lower aerobic capacity during CPET was associated with reduced health-related quality of life and depressive symptoms independent of body mass index, age and FEV1; however, they did not report any data with regard to dyspnoea during or after exercise.…”

Section: Respiratory Muscle Functionmentioning

confidence: 80%

Mechanisms, measurement and management of exertional dyspnoea in asthma

et al. 2017

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Asthma is a heterogeneous condition, with dyspnoea during exercise affecting individuals to a variable degree. This narrative review explores the mechanisms and measurement of exertional dyspnoea in asthma and summarises the available evidence for the efficacy of various interventions on exertional dyspnoea. Studies on the mechanisms of dyspnoea in asthma have largely utilised direct bronchoprovocation challenges, rather than exercise, which may invoke different physiological mechanisms. Thus, the description of dyspnoea during methacholine challenge can differ from what is experienced during daily activities, including exercise. Dyspnoea perception during exercise is influenced by many interacting variables, such as asthma severity and phenotype, bronchoconstriction, dynamic hyperinflation, respiratory drive and psychological factors. In addition to the intensity of dyspnoea, the qualitative description of dyspnoea may give important clues as to the underlying mechanism and may be an important endpoint for future interventional studies. There is currently little evidence demonstrating whether pharmacological or non-pharmacological interventions specifically improve exertional dyspnoea, which is an important area for future research.

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“…O condicionamento físico melhora a função pulmonar dos indivíduos e consequentemente reduz a dispneia, mas é necessário que o paciente mantenha atividades físicas regulares e adequadamente, pois o broncoespasmo pode ser desencadeado pelo exercício físico (MENDES et al, 2013).…”

Section: Introductionunclassified

Influência De Um Programa De Condicionamento Físico Na Qualidade De Vida E Função Pulmonar Em Pacientes Asmáticos

Ferreira¹,

Carreteiro²,

Cappellazzo³

et al. 2016

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This study aimed to analyze the influence of a fitness program on quality of life and lung function in asthmatics. This is an experimental study in which 19 patients were randomized intervention group (n = 9) and control group (n = 10). Later they were divided by age group: patients aged 30 to 40 years and 41-60 years. The intervention group held three times a week totaling 24 sessions of 60 minutes of individual physical training and educational lectures, while the control group received only educational lectures. Quality of life was assessed using the instrument The Asthma Quality of Life Questionnaire, and lung function was assessed by spirometry and chest cirtometry. There was improvement in the score of the control group's quality of life with an average age of 41-60 years and in both the intervention group. In the thoracic mobility, there was an increase of axillary and xiphoid only on average with intervention group aged 30 to 40 years. In spirometry only the control group with an average age of 41 to 60 years showed improvement in all spirometric variables. The results of this study suggest that pulmonary rehabilitation had a positive impact on the treatment of asthmatic patients, improving the quality of life, lung function and chest mobility.

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Association between Maximal Aerobic Capacity and Psychosocial Factors in Adults With Moderate-to-Severe Asthma

Cited by 18 publications

References 30 publications

Intensity of swimming exercise influences tracheal reactivity in rats

Intensity of swimming exercise influences tracheal reactivity in rats

Mechanisms, measurement and management of exertional dyspnoea in asthma

Influência De Um Programa De Condicionamento Físico Na Qualidade De Vida E Função Pulmonar Em Pacientes Asmáticos

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