Constant-Load Exercise Versus High-Intensity Interval Training on Aerobic Fitness in Moderate-to-Severe Asthma: A Randomized Controlled Trial

Silva, Ronaldo Aparecido da; Rocco, Patrícia Gonçalves Leite; Stelmach, Rafaël; Oliveira, Luanda Mara da Silva; Sato, Maria Notomi; Cukier, Alberto; Carvalho, Celso Ricardo Fernandes

doi:10.1016/j.jaip.2022.05.023

Cited by 10 publications

(21 citation statements)

References 41 publications

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“…This study involved 101 individuals with asthma who completed an aerobic training program: 22 from the study by França-Pinto et al, 3 26 from the study by Freitas et al, 6 and 53 from the study by Aparecido da Silva et al, 13 allocated in two groups: interval training group and continuous training group.…”

Section: Resultsmentioning

confidence: 99%

“…This was a post hoc analysis of pooled data from previous randomized controlled trials. 3 , 6 , 13 These trials involved individuals with moderate to severe asthma who had previously participated in a pulmonary rehabilitation program in our center and underwent aerobic training ( Chart 1 ). 3 , 6 , 13 There was no overlap of individuals among the studies.…”

Section: Methodsmentioning

confidence: 99%

“… 3 , 6 , 13 These trials involved individuals with moderate to severe asthma who had previously participated in a pulmonary rehabilitation program in our center and underwent aerobic training ( Chart 1 ). 3 , 6 , 13 There was no overlap of individuals among the studies. All individuals were followed at the same university hospital.…”

Section: Methodsmentioning

confidence: 99%

“…18178013.9.0000.0068). 3 , 6 , 13 All of the participants completed the aerobic training program between 2015 and 2019. Cardiopulmonary exercise test (CPET) variables, asthma clinical control, and quality of life were evaluated before and after the intervention.…”

Section: Methodsmentioning

confidence: 99%

“…Exercise capacity was assessed via a maximal CPET to the limits of tolerance performed either on a treadmill 3 or on a cycle ergometer. 6 , 13 The protocols used were previously established for treadmill 21 , 22 and cycle ergometer. 23 The comparison between predicted VO 2 max values obtained on two ergometers was corrected according to the equation 24 :…”

Section: Methodsmentioning

confidence: 99%

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Characteristics of individuals with moderate to severe asthma who better respond to aerobic training: a cluster analysis

et al. 2023

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Objective: To determine the characteristics of individuals with asthma who are responsive to aerobic training. Methods: This post hoc analysis of pooled data from previous randomized controlled trials involved 101 individuals with moderate to severe asthma who underwent aerobic training. Participants underwent a maximal cardiopulmonary exercise test and completed the Asthma Control Questionnaire and the Asthma Quality of Life Questionnaire before and after a 24-session aerobic training program. Better and worse responders to aerobic training were identified by cluster analysis. Results: Two clusters were identified according to the improvement in peak VO2 after aerobic training (better and worse responders). Characteristics of the better responder group were being older, being female, having higher BMI, and having higher cardiac reserve at baseline when compared with the worse responder group. Also, better responders had worse clinical control, worse quality of life, and lower physical capacity at baseline. After training, worse responders, in comparison with better responders, showed half the improvement in ?peak VO2 (7.4% vs. 13.6%; 95% CI, -12.1 to -0.92%; p < 0.05) and worse asthma control. A weak, negative, but significant association (r = -0.35; p < 0.05) was observed between clinical control and aerobic fitness only in the better responder group. Both groups showed significant improvement in quality of life. Conclusions: Obese individuals with worse exercise capacity, clinical control, and quality of life showed improvement with aerobic training. Moreover, worse responders also improved with training, but to a lesser extent.

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Section: Resultsmentioning

confidence: 99%