Effect of High-Intensity Interval Training on Inhaled Corticosteroid Dose in Asthma Patients: A Randomized Controlled Trial

Pitzner-Fabricius, Anders; Dall, Christian Have; Henriksen, Marius; Hansen, Erik Søren Halvard; Toennesen, Louise Lindhardt; Hostrup, Morten; Backer, Vibeke

doi:10.1016/j.jaip.2023.04.013

Cited by 2 publications

(5 citation statements)

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“…Consequently, interventions that could reduce the consumption of reliever medication are extremely relevant for people with asthma [ 21 ]. Previous studies have demonstrated that CLE reduces ICS consumption in asthma participants [ 14 , 15 ], and an elegant recent study showed that HIIT also reduced ICS consumption after a period of 12 months of intervention [ 16 ], but to the best of our knowledge, SABA consumption has never been evaluated. Therefore, our study provides new information by showing that individuals with asthma who required more SABA consumption reduced their pre-exercise consumption and their total consumption during the intervention.…”

Section: Discussionmentioning

confidence: 99%

“…Participation was voluntary, and all provided informed consent before participation. The exclusion criteria were as follows: cardiovascular and musculoskeletal diseases or other chronic lung diseases; current participation in an exercise programme; and current smokers or ex-smokers (>10 pack-years) [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

“…[ 15 ] demonstrated that CLE reduces ICS consumption in children with asthma, and P itzner- F abricius et al . [ 16 ] showed a reduction of ICS after a HIIT programme; however, reliever medication consumption as SABA before and after exercise intervention was not standardised at that time. Furthermore, in the past decade, studies aiming to insulate the effect of exercise on people with asthma have been performed between two medical appointments to avoid changes in medication during the intervention [ 10 , 11 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of constant-load exercise and high-intensity interval training on reliever medication consumption and peak expiratory flow in individuals with asthma: a randomised controlled trial

da Silva,

Cukier,

Carvalho-Pinto

et al. 2024

ERJ Open Res

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IntroductionThe effect of aerobic training (AT) on reliever medication consumption (short-action beta-2 agonist (SABA)) and peak-expiratory flow (PEF) in participants with asthma is poorly known. The comparison between constant-load exercise (CLE) and high-intensity interval training (HIIT) in these outcomes has never been tested.PurposeTo compare the effects of CLE or HIIT in SABA consumption and PEF improvement during an exercise program in subjects with asthma.MethodsClinically stable participants were randomized into CLE (n=27; 70–85% of the maximal load (Wmax)) or HIIT (n=28; 80–140%Wmax). The program lasted 12 weeks (twice/week, 40 min/session), and the intensity was based on cardiopulmonary exercise testing (CPET). The PEF was assessed before and after each exercise session. SABA was used if the PEF was <70%. Clinical control (Asthma Control Questionnaire (ACQ-6)), CPET, and aerobic fitness were also assessed before and after the intervention.ResultsBoth groups were similar at baseline. CLE and HIIT reduced SABA consumption throughout the intervention (p<0.05). Before training, 14 patients required SABA before exercising, but only one needed it after the intervention. Changes in post-exercise PEF were lower in the CLE than in the HIIT (1.6±25.3versus10.3±13.7%). Both groups also improved aerobic fitness (10.1±12.8versus5.7±15.6%) and clinical asthma control; however, only the HIIT group achieved a minimal clinically important difference in the ACQ post-intervention (−0.23±1.06versus−0.52±0.73 delta score).ConclusionCLE and HIIT reduced SABA consumption; however, only HIIT increased PEF and asthma clinical control after the intervention. These results reinforce the importance of exercise training in moderate-to-severe asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of constant-load exercise and high-intensity interval training on reliever medication consumption and peak expiratory flow in individuals with asthma: a randomised controlled trial

da Silva,

Cukier,

Carvalho-Pinto

et al. 2024

ERJ Open Res

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“…A recent randomized exercise study in patients with asthma demonstrated that six months of exercise training led to a sustained reduction in ICS dose even six months after the completion of the intervention. This suggests a durable impact of exercise or a change in the training habits of the participants [ 36 ]. To better our understanding of the long-term effects of exercise in asthma, follow-up studies should be conducted following exercise intervention studies.…”

Section: Discussionmentioning

confidence: 99%

“…In general, our study weighs into the increasing amounts of evidence suggesting that exercise is a viable treatment of asthma [ 24 , 36 ]. We did not observe any major adverse effects of training nor did the participants who undertook training report respiratory worsenings.…”

Section: Discussionmentioning

confidence: 99%

The effect of aerobic exercise training on asthma control in postmenopausal women (ATOM): a randomized controlled pilot study

Hansen,

Rasmusen,

Hostrup

et al. 2023

European Clinical Respiratory Journal

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Objective To evaluate if high-intensity interval training three times weekly for 12 weeks improves asthma control in overweight, postmenopausal women with uncontrolled, late-onset asthma. Methods The reported study is a randomized clinical pilot study ( www.clinicaltrials.gov ; NCT03747211) that compared 12 weeks of high-intensity interval training (spinning) with usual care. The five-question Asthma Control Questionnaire (ACQ-5) was used as primary outcome. Secondary measures included systemic inflammation and inflammation of the airways, body composition, and cardiac function during exercise. Results We included 12 women with asthma (mean age 65 years (SD 6); mean body mass index 30 kg/m 2 (SD 2)) from whom eight were randomized to exercise and four to control. Baseline ACQ-5 was 1.95 (SD 0.53) in the control group and 2.03 (0.54) in the exercise group. Patients had a mean blood eosinophil level of 0.16 × 10 9 cells/L (SD 0.07) and a mean fraction of exhaled nitric oxide of 23 ppb (SD 25). Mixed models showed that participants in the exercise group reduced their ACQ-5 by 0.55 points (95%CI −1.10 to −0.00; P = 0.08) compared with the control group. The exercise group significantly reduced their mean body fat percentage (−2.7%; 95%CI −4.5 to −0.8; P = 0.02), fat mass (−2.8 kg; 95%CI −5.1 to −0.4; P = 0.044) and android fat mass (−0.33 kg; 95%CI −0.60- −0.06; P = 0.038). In analyses of cardiac measures, we saw no significant effects on right ventricular function (fractional area change), diastolic function or left ventricular function. Conclusions Although changes in ACQ-5 were slightly insignificant, these preliminary findings indicate that aerobic exercise training can be used as a means to improve asthma control in overweight, postmenopausal women with asthma.

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Effect of High-Intensity Interval Training on Inhaled Corticosteroid Dose in Asthma Patients: A Randomized Controlled Trial

Cited by 2 publications

References 41 publications

Effects of constant-load exercise and high-intensity interval training on reliever medication consumption and peak expiratory flow in individuals with asthma: a randomised controlled trial

Effects of constant-load exercise and high-intensity interval training on reliever medication consumption and peak expiratory flow in individuals with asthma: a randomised controlled trial

The effect of aerobic exercise training on asthma control in postmenopausal women (ATOM): a randomized controlled pilot study

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