Comparison of the Effects of Aerobic Conditioning Before and After Pulmonary Allergic Inflammation

Silva, Ronaldo Aparecido da; Almeida, Francine Maria de; Olivo, Clarice Rosa; Saraiva-Romanholo, Beatriz Mangueira; Perini, Adenir; Martins, Mílton A.; Carvalho, Celso Ricardo Fernandes

doi:10.1007/s10753-014-0090-0

Cited by 6 publications

(9 citation statements)

References 39 publications

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“…However, unlike the previous studies, IgE and IgG 1 titers decreased in OVA + AE group as well as total lung IgE. These results may be explained by the ability of AE to attenuate macrophage activation and antigen presentation to B lymphocytes [37]. Besides antigen presentation modulation, the improvements promoted by AE in asthma are attributed to the increase in anti-inflammatory cytokines.…”

Section: Discussioncontrasting

confidence: 72%

“…Several experimental models in mice have shown that AE mitigated an OVA-induced lung inflammation and remodeling. However, in these studies, AE was not able to modify the levels of immunoglobulins, as shown by Pastva et al (2004) and Silva et al (2015) [31,37]. Therefore, the aim of this study was to evaluate the effects of AE performed for 2 weeks following OVA sensitization and before a single allergen aerosol challenge.…”

Section: Introductionmentioning

confidence: 97%

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Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model

et al. 2017

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Aerobic exercise (AE) reduces lung function decline and risk of exacerbations in asthmatic patients. However, the inflammatory lung response involved in exercise during the sensitization remains unclear. Therefore, we evaluated the effects of exercise for 2 weeks in an experimental model of sensitization and single ovalbumin-challenge. Mice were divided into 4 groups: mice non-sensitized and not submitted to exercise (Sedentary, n=10); mice non-sensitized and submitted to exercise (Exercise, n=10); mice sensitized and exposed to ovalbumin (OVA, n=10); and mice sensitized, submitted to exercise and exposed to OVA (OVA+Exercise, n=10). 24 h after the OVA/saline exposure, we counted inflammatory cells from bronchoalveolar fluid (BALF), lung levels of total IgE, IL-4, IL-5, IL-10 and IL-1ra, measurements of OVA-specific IgG1 and IgE, and VEGF and NOS-2 expression via western blotting. AE reduced cell counts from BALF in the OVA group (p<0.05), total IgE, IL-4 and IL-5 lung levels and OVA-specific IgE and IgG1 titers (p<0.05). There was an increase of NOS-2 expression, IL-10 and IL-1ra lung levels in the OVA groups (p<0.05). Our results showed that AE attenuated the acute lung inflammation, suggesting immunomodulatory properties on the sensitization process in the early phases of antigen presentation in asthma.

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Section: Discussioncontrasting

confidence: 72%

Section: Introductionmentioning

confidence: 97%

Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model

et al. 2017

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“…. However, more recent studies have also identified immunomodulatory effects of regular physical exercise, including reduced susceptibility to viral illness, improved redox balance in the lung, and attenuated inflammatory responses to bacterial products such as LPS . Other studies have demonstrated the converse: brief intense or prolonged vigorous exercise may temporarily increase inflammation in the lung and susceptibility to infection .…”

Section: Promising Approaches Toward Effective and Safe Anti‐inflammamentioning

confidence: 99%

Inflammation and its genesis in cystic fibrosis

Nichols

Chmiel

2015

Pediatric Pulmonology

162

150

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Summary. The host inflammatory response in cystic fibrosis (CF) lung disease has long been recognized as a central pathological feature and an important therapeutic target. Indeed, many believe that bronchiectasis results largely from the oxidative and proteolytic damage comprised within an exuberant airway inflammatory response that is dominated by neutrophils. In this review, we address the longstanding argument of whether or not the inflammatory response is directly attributable to impairment of the cystic fibrosis transmembrane conductance regulator or only secondary to airway obstruction and chronic bacterial infection and challenge the importance of this distinction in the context of therapy. We also review the centrality of neutrophils in CF lung pathophysiology and highlight more recent data that suggest the importance of other cell types and signaling beyond NF-kB activation. We discuss how protease and redox imbalance are critical factors in CF airway inflammation and end by reviewing some of the more promising therapeutic approaches now under development. Pediatr Pulmonol. 2015;50:S39-S56.

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“…Th2 cells synthesize high levels of interleukins IL-4, IL-5, and IL-13, which leads to the production of allergen-specific immunoglobulin (Ig) E and the release of mediators from mast cells [17]. Th1 cells suppress Th2 immune responses by secreting interferon IFN-γ.…”

Section: Discussionmentioning

confidence: 99%

Anti-Asthmatic Effects of Ginsenoside Rb1 in a Mouse Model of Allergic Asthma Through Relegating Th1/Th2

et al. 2015

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The aim of the study was to investigate the anti-asthma effects of ginsenoside Rb1 (Rb1) and its possible mechanisms. A total of 50 mice were randomly assigned to five experimental groups: control, model, dexamethasone (2 mg/kg), and Rb1 (10 and 20 mg/kg). Airway resistance (RI) was measured; histological studies were evaluated by the hematoxylin and eosin (HE) staining; Th1/Th2, ovalbumin (OVA)-specific serum, and bronchoalveolar lavage fluid (BALF) IgE levels were evaluated enzyme-linked immunosorbent assay (ELISA); and T-bet/GATA3 proteins were evaluated by Western blot. Our study demonstrated that Rb1 inhibited OVA-induced increases in RI and eosinophil counts; interleukin (IL)-4 was recovered, and IFN-γlevel increased in bronchoalveolar lavage fluid. Histological studies demonstrated that Rb1 substantially inhibited OVA-induced eosinophilia in lung tissue. Western blot studies demonstrated that Rb1 substantially inhibited GATA3 and increased T-bet. These findings suggest that Rb1 may effectively ameliorate the progression of asthma and could be used as a therapy for patients with allergic asthma.

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Comparison of the Effects of Aerobic Conditioning Before and After Pulmonary Allergic Inflammation

Cited by 6 publications

References 39 publications

Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model

Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model

Inflammation and its genesis in cystic fibrosis

Anti-Asthmatic Effects of Ginsenoside Rb1 in a Mouse Model of Allergic Asthma Through Relegating Th1/Th2

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