Polycystic ovarian syndrome (PCOS) is caused by abnormal production of androgens resulting in the formation of small fluid-filled sacs in the ovaries. This condition worsens the life quality of women by disturbing their physiology and psychology in reproductive age. PCOS may also be associated with other morbidities like diabetes and hypertension. Numerous factors like imbalanced dietary patterns, poor lifestyle activities, improper care and medication, late diagnosis, and ignorance are involved in the prevalence of this disease in women. Hence, an early diagnosis and improved dietary and lifestyle management may improve the life quality and timely recovery of the patient from this disease. Various herbal extracts show a positive correlation in reducing the indicators associated with PCOS. This review discusses the effect of dietary and lifestyle practices on PCOS as prominent features. It has been recommended that a balanced diet with 40% energy from carbohydrates, 30% from fats, and 30% from protein with optimum physical activity could reduce severe PCOS symptoms and improve metabolic balance. Furthermore, recommendations for modification of diet and lifestyle activities are made which may positively influence the recovery from PCOS. Practical applicationsPolycystic ovarian syndrome (PCOS) severely affects the life quality of suffering women. The dietary patterns, lifestyle activities, and co-medical conditions collectively affect the severity and related consequences of PCOS. This article provides sufficient information on dietary and lifestyle modifications to effectively manage this disease. Furthermore, dietitians, nutritionists, gynecologists, and obstetrics physicians can benefit from the information provided in it to understand and develop the management strategies to alleviate the disease symptoms and severity.
Drought stress induces the formation of cortical aerenchyma in roots, providing drought tolerance by reducing respiration. However, unrestricted aerenchyma formation impedes the radial transport of water through the root's central cylinder; thereby decreasing the water uptake under drought stress. Therefore, exploring the root architectural and anatomical alterations in rice under drought is essential for targeting crop improvement. Drought stress-induced accumulation of reactive oxygen species (ROS) plays a key role in the lysigenous aerenchyma development. However, the influence of nitric oxide (NO) and reactive nitrogen species (RNS) in the development of lysigenous aerenchyma under drought has never been studied in rice. The present study examined the effect of ROS and RNS, generated by progressive drought stress, on the lysigenous aerenchyma formation in the roots of contrasting rice genotypes of the Eastern Indo-Gangetic plains (EIGP). As expected, the PEG-induced drought stress stimulated the expression of NADPH oxidase (NOX), thereby promoting the ROS generation in roots of the rice seedlings. Excessive ROS and RNS accumulations in roots affected the membrane lipids, promoting the tissue-specific programmed cell death (PCD) in rice. The activation of the antioxidant defense system played a major role in the ROS and RNS detoxification, thereby restricting the root aerenchyma formation in rice under drought stress. The results also displayed that drought tolerance in rice is associated with the formation of the Casparian strip, which limits the apoplastic flow of water in the water-deficient roots. Overall, our study revealed the association of nitro-oxidative metabolism with PCD and lysigenous aerenchyma formation in the cortical cells of root under drought stress in rice.
Venous thromboembolism (VTE) was once considered a rare finding in pediatric population but it has been increasing with recent advances in medical care and technology to diagnose it. This study was conducted to determine the clinical presentation, associated factors and outcome of VTE in hospitalized children in a tertiary care children hospital of Karachi. This descriptive cross sectional study was conducted at National Institute of Child Health, Karachi from December 2020 to January 2022. All patients hospitalized with VTE or who were diagnosed to have DVT while at hospital were included in study. Demographic characteristics, clinical presentation, medical history and laboratory workup was recorded in a semi-structured proforma. Patients were managed by treating physicians as per hospital protocol. Treatment details were recorded along with outcome. A Total of 36 children were diagnosed with VTE. Nine (25%) patients were admitted with clinical features suggestive of DVT while remaining 27 (75%) developed DVT during hospital stay. Median hospital stay of those who developed DVT at hospital was 15 days (IQR 10-30days). Infectious etiology (n=21, 58.3%) was the most common admitting diagnosis followed by central nervous system disorders (n=4, 11.1%). Common clinical features among VTE children were fever, seizures and edema of limbs. Prolonged hospital stay with immobilization and central venous catheterization particularly due to infectious etiology are common factors among children who develop VTE and such patients need to be considered for VTE prophylaxis and treatment.
Originating with unexplained symptoms from Wuhan, city of China, COVID-19 being a global pandemic causing tremendous morbidity and mortality, has proved to be the biggest challenge of the 20th century. This study aimed to explore the functional impacts of COVID-19 upon those patients who were diagnosed with this disease and were admitted in hospitals. This cross-sectional survey included 183 COVID-19 diagnosed patients from COVID-19 isolation wards of public and private hospitals of Islamabad and Rawalpindi. After getting ethical permission from Institutional Review Board of Shifa International Hospital (Ref # 070-21), this survey was conducted for the time period of 6 months from December 2020 to May 2021. Through convenient sampling, 183 patients with the age range of 25 to 55 years with no already diagnosed psychological complaints were assessed for eligibility briefed regarding the study purpose and then were asked for their voluntary participation. The Functional Status Scale for the Intensive Care Unit (FSS-ICU) was used to assess the functional status impacted due to COVID-19 during hospitalization. Frequencies and percentages were calculated through SPSS-21. On FSS-ICU, out of 183 COVID-19, 11 (6%) patients reported that they were dependent, 18 (9.8%) required maximum assistance, 32 (17.5%) required moderate assistance, 27 (14.8%) required minimal, 24 (13.1%) required supervision to complete their tasks, 28 (15.3%) required assistive devices, whereas 43 (23.5%) were totally independent. Results indicated a temporal impact of COVID-19 upon functional status of hospitalized patients in intensive care units, therefore highlighting the need of physiotherapeutic and psychotherapeutic interventions.
In millennia, medicinal plants have gained greater interest owing to the presence of a broad spectrum of bioactive compounds which possess potential health benefits. Among these functional plants, cinnamon verum has captured more attention due to its multiple medicinal activities. In this review article, efforts were made to overview the functional properties of cinnamon verum with special reference to type II diabetes. Literature demonstrated that cinnamon verum possesses different pharmaceutical activities such as antioxidant, antibacterial, anti-inflammatory, anticancer, antidiabetic, wound recuperating, anti-HIV, anti-anxiety, and antidepressant activities. Moreover, hypoglycemic activity of cinnamon verum is attributed to the presence of various bioactive compounds especially cinnamaldehyde and other components of extract and essential oil.
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