<b><i>Background:</i></b> Capsaicin, the main pungent ingredient in hot chili peppers, causes excitation of small sensory neurons. It also provides the basic pungent flavor in <i>Capsicum</i> fruits. <b><i>Summary:</i></b> Capsaicin plays a vital role as an agonist for the TRPV1 (transient receptor potential cation channel, subfamily V, member 1) receptor. TRPV1 is essential for the reduction of oxidative stress, pain sensations, and inflammation. Therefore, it has many pros related to health issue. Activation and positive impact of TRPV1 via capsaicin has been studied in various dermatological conditions and in other skin-related issues. Past studies documented that capsaicin plays a vital role in the prevention of atopic dermatitis as well as psoriasis. Moreover, TRPV1 is also very important for skin health because it acts as a capsaicin receptor. It is found in nociceptive nerve fibers and nonneural structures. It prompts the release of a compound that is involved in communicating pain between the spinal cord nerves and other parts of the body. <b><i>Key Messages:</i></b> Here, we summarize the growing evidence for the beneficial role of capsaicin and TRPV1 and how they help in the relief of skin diseases such as inflammation, permeation, dysfunction, atopic dermatitis, and psoriasis and in pain amplification syndrome.
There are many causes and factors that lead towards depressions including hypertension, illness, chronic diseases, physical illness, some medications, but one of the major causes regarding nutritional point of view for depression is zinc deficiency. Zinc is a trace mineral which is required by our body in a minute amount. From many researches zinc has been entitled as an important element for normal physiological as well as pathological functioning. Zinc has a lot of biological functions in our body like in immune system, growth and development, reproductive system, diarrhea, respiratory infections, wound healing, hair loss, decreased levels of t helper cells and many more. Zinc acts as antioxidant, anti-inflammatory and also in the process of apoptosis. Zinc plays fundamental role in cellular metabolism and modulates the synaptic activity of cells. Zinc also plays its role at molecular level by regulating the expression of genes. Zinc deficiency can cause many clinical problems. It can affect our neurological system as well as neurodegenerative system and hence it can be a cause of depression, anxiety, dementia, Alzheimer’s disease, and many more. Therefore, this article aimed to highlight the important role of zinc in reducing the severity of depression
Handling industrial agricultural wastes is a requirement for industrial waste management in the context of circular bioeconomy innovations. The recovery and re-use of agricultural wastes and their by-products have become an important topic of research and development to investigate their functional and nutraceutical properties. The bioeconomy provides an opportunity to create innovative bio-based products and processes, thereby opening up new markets. Agricultural waste contains a high concentration of protein, fat, carbohydrates, fiber, and other functional compounds such as antioxidants, which can be used to add value to a variety of food products. Due to its higher nutritional profile, cereal bran, as an agricultural waste and by-product, has a variety of functional and nutraceutical properties. Despite the fact that it is rich in bioactive compounds with health benefits, cereal bran is still underutilized in the food system. It can be used either directly for the processing of various foods or the extraction of various bioactive components present therein. Furthermore, the extracts from cereal bran have been used to obtain antioxidants, antibiotics, vitamins, and enzymes as functional components to be employed in agri-food and animal feed, pharmaceutical, and cosmetics industries. Therefore, this review aims to promote cereal bran waste and by-products, highlighting how to use them as functional ingredients with health-promoting properties and desirable technological aspects. Currently, there are few data on the nutritional exploration of these by-products as health-promoting agri-food products. Cereal bran is a nutritious natural agricultural by-product, but its potential application in the food industry is still limited due to a lack of literature focused on its quality attributes, which may become useful for informal explanation and evaluation during food product formulation. With the growing demand for fiber-rich foods, cereal bran valorization can generate revenue for milling industries.
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