Purpose: To determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair. Methods: Thirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further subdivided into three subgroups (days 7, 14, and 21; n = 5 each). Samples were analyzed histologically. Results: Histological analysis showed a significant reduction in inflammatory infiltrates on days 7, 14 (p < 0.0001 for both), and 21 (p = 0.0004) in the membrane group compared to that in the control group. There was also a significant decrease in the number of fibroblasts in the control group on days 7, 14 (p < 0.0001), and 21 (p = 0.0032). Further, an increase in type I collagen deposition was observed in the membrane group compared to that in the control group on days 7 (p = 0.0133) and 14 (p = 0.0107). Conclusion: Treatment with norbixin-based PHB membranes reduces the inflammatory response, increases fibroblast proliferation, and improves collagen production in the tendon repair region, especially between days 7 and 14.Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats Nascimento LDS et al. Acta Cir Bras. 2019;34(11):e201901101Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats Nascimento LDS et al. Cir Bras. 2019;34(11):e201901101
ActaEffect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats Nascimento LDS et al.
This review presents the survey of performance of biomaterials prepared using norbixina and poly(hydroxybutyrate) as biomaterials in biological applications. Biomaterials can replace and/or stimulate biological systems that no longer have their functions, such as the restoration of tissue functions. In the field of biomaterials, norbixin is an antioxidant dicarboxylic carotenoid found in Bixa orellana L. and poly(hydroxybutyrate) (PHB) is a natural polymer that has characteristics of biodegradability and biocompatibility. There is a shortage of studies involving such constituents together as biomembranes in tissue healing with repair of cutaneous wounds or bone regeneration, although both present promising research that suggests its effectiveness as a guide for tissue regeneration.
PURPOSE:To evaluate in a macroscopic, histological and histomorphometric manner the healing process of cutaneous wounds in mice.
METHODS:
RESULTS:It was observed that in the acute phase the AlGaInP Laser at 5 J/cm 2 provided a greater stimulus to healing, and both lasers were effective in the remodeling phase.
CONCLUSION:The AlGaInP lasers from 5 J/cm 2 to 8 J/cm 2 showed better biomodulatory results in the acute and remodeling phases respectively, however, the HF was less effective than the laser, providing significant benefits only in the acute phase of tissue repair.
Conception, design, intellectual and scientific content of the study; acquisition and interpretation of data; technical procedures; manuscript preparation and writing. II PhD, Collaborator, Postgraduate Program in Biomedical Engineering of the Research and Development Institute, UNIVAP, Sao Jose dos Campos-SP, Brazil. Conception, design, intellectual and scientific content of the study; interpretation of data; critical revision; final approval.
A Cefaleia do Tipo Tensional (CTT) está associada a pontos-gatilho (PG) situados nos músculos da cabeça e pescoço. A liberação miofascial (LM) possui técnicas fundamentais para desativação dos mesmos e de seus sintomas. Objetivou-se verificar os efeitos da LM na descrição e frequência da dor em mulheres com CTT induzida por PG. A amostra foi constituída de nove mulheres com 42,67 ± 6,84 anos, selecionados através de uma Ficha de Triagem. As mesmas foram avaliadas e, antes e após o tratamento, foi aplicado o Questionário McGill. Inicialmente, as participantes não receberam atendimento e preencheram o Diário de Cefaleia (DC), em domicílio, durante um mês; em seguida, continuaram preenchendo DC e iniciaram o tratamento com técnicas LM, duas vezes/semana, 16 atendimentos. Variáveis analisadas: descrição e frequência da dor. Os dados foram analisados através do teste paramétrico “t” de Student, com nível de significância de p ≤ 0,05. Houve redução dos scores de PRI e NWC do Questionário McGill e da frequência da dor nos parâmetros dias/mês e vezes/mês. Conclui-se que o tratamento fisioterapêutico com LM apresentou resultados significativos na redução da intensidade subjetiva global da dor, alívio dos componentes sensoriais e afetivos e diminuição da frequência da dor em mulheres com CTT.Palavras-chave: cefaleia do tipo tensional, pontos-gatilho, terapia manual.
<p>É crescente a associação de matrizes poliméricas e extratos naturais para a confecção de novos biomateriais na área de engenharia de tecidos. O presente trabalho propõe um estudo prospectivo sobre a aplicação de uma matriz polimérica contendo poli-hidroxibutirato e o apocarotenoide norbixina como biomaterial para fins de reparo ósseo. Foram realizadas buscas de artigos científicos publicados nos últimos dez anos, entre 2008 e 2018, nas bases de periódicos Web of Science, Scopus e Scielo. Para o mapeamento científico e tecnológico, considerou-se o levantamento total do número de patentes nos bancos de patentes do INPI, Espacenet e USPTO. A partir dos artigos e patentes revisados, constatou-se que a associação desses constituintes na engenharia de tecidos e em reparo ósseo é desconhecida. Porém, observou-se que os mesmos são conhecidamente utilizados como biomateriais com relevantes propriedades terapêuticas em diversos meios biológicos, tratando-se, portanto, de uma promissora área de pesquisa a ser explorada.</p>
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