Among conventional cancer therapies, radio-frequency magnetic hyperthermia (MHT) has widely been investigated for magnetic nanoparticles (MNPs). However, majority of in vivo biodistribution studies have tested very low MNP dosages (equivalent...

In this research work, designing and fabrication of hybrid epoxy polymer composite materials had been carried out. It consists of basalt fiber (constant fraction) and marble dust particulates (0–10 wt% @ step of 2.5%) ensuing five compositions namely, MBE-0, MBE-2.5, MBE-5, MBE-7.5, and MBE-10. The specimen’s undergone physical, mechanical, and thermo-mechanical characterizations followed by three-body abrasive wear performance evaluation. Parametric optimizations of the wear have been evaluated with the Taguchi technique. The performance data are used to rank the compositions using a hybrid AHP-VIKOR selection making tool. It has been observed that voids content improves with reinforcement up to 5 wt% marble dust reinforcement, thereafter, it deteriorates sharply. The mechanical properties with 5 wt% marble dust reinforcement found to be highest. The thermo-mechanical characteristics like modulus and damping improve with marble dust reinforcement and temperature. The Cole-Cole plots reveal the heterogeneity present in the composites. The Taguchi’s analysis reveals the order of operating factors influencing specific wear rate as abrading distance > normal load > reinforcement composition > abrasive size. The steady state-specific wear rate of the composites reveals decremented rate across the abrading distance range irrespective of reinforcement proportions and at any specific abrading distance the order it followed as MBE-5 < MBE-7.5 < MBE-2.5 < MBE-10 < MBE-0. The ranking analysis using hybrid AHP-VIKOR technique predicts the ranking sequence as MBE-5 > MBE-7.5 > MBE-2.5 > MBE-10 > MBE-0, which are in-line with subjective analysis.

Understanding the mode of gene action that controls seed yield and Sclerotinia stem rot resistance in Indian mustard is critical for boosting yield potential. In a line × tester mating design, ten susceptible lines and four resistant testers were used to conduct genetic analysis. The significance of general combining ability (GCA) and specific combining ability (SCA) variances revealed that both additive and non-additive gene actions were involved in the inheritance of Sclerotinia stem rot resistance and yield attributing traits. In addition to 1000-seed weight and number of primary and secondary branches/plant, the genotypes RH 1569 (line) and DRMR 2035 (tester) appeared to be the strongest general combiners for Sclerotinia stem rot resistance. RH 1657 × EC 597317 was the only cross among several that demonstrated a significant desired SCA value for Sclerotinia rot resistance. Regarding SCA effects for yield and component traits, the cross RH 1658 × EC 597328 performed best, with a non-significant but acceptable negative SCA effect for resistance. DRMR 2035, RH 1222-28, RH 1569, RH 1599-41, RH 1657, RH 1658, and EC 597328 are promising genotypes to use as parents in future heterosis breeding and for obtaining populations with high yield potential and greater resistance to Sclerotinia stem rot disease in Indian mustard, based on GCA effects of parents, per se performance, and SCA effects of hybrids. Days to 50% flowering, number of primary branches/plant, main shoot length, and 1000-seed weight all had a high genotypic coefficient of variability (GCV), broad-sense heritability (h2bs), and genetic advance as percent of the mean (GAM) values, as well as significant and desirable correlations and direct effects on seed yield. As a result, these traits have been recognized as the most critical selection criterion for Indian mustard breeding programs.

Background: Seasonal allergic conjunctivitis is the most common allergic disorder seen in eyes. The aim of study was to compare the clinical efficacy of combination of 0.4% ketorolac and 0.1% olopatadine with 0.4% ketorolac alone in seasonal allergic conjunctivitis. Material and Method: The study was prospective, double blind parallel group comparative. Two hundred cases enrolled in the study. All the subjects were randomly divided in two groups, 100 in each. Group 1 patients received 0.4% ketorolac eye drop in both eyes 2 times a day and group 2 patients received combination of 0.1% olopatadine and 0.4% ketorolac in both eyes 2 times a day. Observations were collected at baseline and on day 3,7,15 and analyzed statistically regarding improvement in sign and symptoms. Result: In group 1, 50-60% patients had no sign and symptoms on day 15 whereas in group 2 more than 95% patients showed improvement in clinical picture. p value was significant (p<0.0001) at day 15 in all sign and symptoms and on day 3 in itching and on day 7 in watering. Overall group 2 patients had better and earlier response regarding symptoms of itching at day 3. Conclusion: The combination of 0.1% olopatadine and 0.4% ketorolac was more effective than 0.4% ketorolac alone in seasonal allergic conjunctivitis patients.

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