as a visiting professor under Alexander von Humboldt Fellowship. His research contributions are in the field of medicinal as well as synthetic organic chemistry by developing the chemistry of 2-pyranone.

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Flavones are well known for their antioxidant activity, and are unique in that they are present in the majority of fruits and vegetables. The majority of metabolic diseases are speculated to originate from oxidative stress, and it is therefore significant that recent studies have shown the positive effect of flavones on diseases related to oxidative stress. Due to the wide range of biological activities of flavones, their structure-activity relationships have generated interest among medicinal chemists, and this has culminated into the discovery of the clinical anticancer agent flavopiridol 97, as well as several lead molecules in other disease areas. In this review, the roles of flavones in various metabolic and systemic disease models are discussed.

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One aryl or two? The title reaction predominantly gives monoarylation products with various amounts of diarylation product being observed in almost all cases (see scheme). Aryl iodides as well as aryl bromides were reactive under the optimized reaction conditions. The multiple nitrogen atoms in the purine, and oxygen atoms in the saccharide posed no problems in these transformations.

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