Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines

Crystal structure of (E)-2-(4-hydroxy-3-methoxybenzylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one, C19H18O4

“…Acid catalyzed synthesis is also well established using p-toluene sulfonic acid under focused microwave irradiation [8], thionyl chloride [9], dry hydrochloric acid and borontri uoride-etherate [10]. Some chalcones are known for their biological activities as they exhibit cytotoxic [11], antibacterial [12], antifungal [13], antimalarial and antitubercular [14], anti-in ammatory [15], antimalarial [16], antiviral [17], tyrosinase inhibitor [18], antiallergenic [19], antioxidant [20] and antihyperglycemic [21] activities. The asymmetric unit cell of the titled compound contains one independent molecule.…”

Crystal structure of (2E)-3-(4-benzyloxyphenyl)-1-(4,4’’-difluoro-5’- methoxy-1,1’:3’,1’’-terphenyl-4’-yl)prop-2-en-1-one, C35H26F2O3

“…Chalconesare highly reactive substances of varied nature. They have been reported to possess many interesting pharmacological activities [2] including anti-inflammatory, antimicrobial, antifungal, antioxidant, cytotoxic, antitumor and anticancer activities [3,4].Inview of the pharmacological importance of terphenyls and chalcones and in continuation of our work on the synthesis of various derivatives of 4,4'-difluoro chalcone [5][6][7][8] we herein report the crystal and molecular structure of the title compound. The C=C double bond shows (E)-configuration.…”

4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents

“…NaOH solution (1.5 mL) was added to a well stirred solution of N-(p-acetylphenyl)acetamide (1.7 mmol) and the appropriate substituted benzaldehyde (1.7 mmol) in methanol (50 mL). The reaction mixture was stirred overnight at room temperature, according to the previously described methodology [14]. It was then neutralized with 1N HCl and the product filtered and extracted with chloroform.…”