Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice

Saxena, Gunjan; Singh, Sheelendra Pratap; Pal, Rishi; Singh, S. P.; Pratap, Ramendra; Nath, Chandishwar

doi:10.1016/j.pbb.2007.03.010

Cited by 101 publications

(47 citation statements)

References 30 publications

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“…Although, there are several experimental models in rodents for dementia and associated disorders of neurodegeneration STZ induced dementia model in rats is commonly used in preclinical studies. Central or icv STZ causes neuronal damage in the brain by producing free radicals, thereby inducing the state of oxidative stress, impairment of glucose utilization and demyelination (Saxena et al 2007(Saxena et al , 2008(Saxena et al , 2010. In the present study STZ administration resulted in significant memory deficit as mirrored in the learning and memory tests performed namely, MWM and NORT.…”

Section: Discussionsupporting

confidence: 50%

Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats

2016

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There is strong evidence that mitochondrial dysfunction mediated oxidative stress results in aging and energy metabolism deficits thus playing a prime role in pathogenesis of Alzheimer's disease, neuronal death and cognitive dysfunction. Evidences accrued in empirical studies suggest the antioxidant, anticancer and anti-inflammatory activities of the phytochemical pterostilbene (PTS). PTS also exhibits favourable pharmacokinetic attributes compared to other stilbenes. Hence, in the present study, we explored the neuroprotective role of PTS in ameliorating the intracerebroventricular administered streptozotocin (STZ) induced memory decline in rats. PTS at doses of 10, 30 and 50 mg/kg, was administered orally to STZ administered Sprague-Dawley (SD) rats. The learning and memory tests, Morris water maze test and novel object recognition test were performed which revealed improved cognition on PTS treatment. Further, there was an overall improvement in brain antioxidant parameters like elevated catalase and superoxide dismutase activities, GSH levels, lowered levels of nitrites, lipid peroxides and carbonylated proteins. There was improved cholinergic transmission as evident by decreased acetylcholinesterase activities. The action of ATPases (Na ? K ? , Ca 2? and Mg 2? ) indicating the maintenance of cell membrane potential was also augmented. mRNA expression of battery of genes involved in cellular mitochondrial biogenesis and inflammation showed variations which extrapolate to hike in mitochondrial biogenesis and abated inflammation. The histological findings corroborated the effective role of PTS in countering STZ induced structural aberrations in brain.

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Section: Discussionsupporting

confidence: 50%

Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats

2016

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“…The shock was not delivered in the retention trials to avoid reacquisition. The criterion for learning was taken as an increase in the TLT on retention trials as compared to acquisition trial (Saxena et al 2007;Tota et al 2009Tota et al , 2011.…”

Section: Passive Avoidance Testmentioning

confidence: 99%

Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function

et al. 2012

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Rational Inhibition of renin-angiotensin system (RAS) improves cognitive functions in hypertensive patients. However, role of AT1 and AT2 receptors in memory impairment due to cholinergic hypofunction is unexplored. Objective This study investigated the role of AT1 and AT2 receptors in cerebral blood flow (CBF), cholinergic neurotransmission, and cerebral energy metabolism in scopolamineinduced amnesic mice. Methods Scopolamine was given to male Swiss albino mice to induce memory impairment tested in passive avoidance and Morris water maze tests after a weeklong administration of blocker of AT1 receptor, candesartan, and AT2 receptor, PD123, 319. CBF was measured by laser Doppler flowmetry. Biochemical and molecular studies were done in cortex and hippocampus of mice brain. Results Scopolamine caused memory impairment, reduced CBF, acetylcholine (ACh) level, elevated acetylcholinesterase (AChE) activity, and malondialdehyde (MDA). Administration of vehicle had no significant effect on any parameter in comparison to control. Candesartan prevented scopolamineinduced amnesia, restored CBF and ACh level, and decreased AChE activity and MDA level. In contrast, PD123, 319 was not effective. However, the effect of AT1 receptor blocker on memory, CBF, ACh level, and oxidative stress was blunted by concomitant blockade of AT2 receptor. Angiotensin-converting enzyme (ACE) activity, ATP level, and mRNA expression of AT1, AT2, and ACE remained unaltered. Conclusion The study suggests that activation of AT1 receptors appears to be involved in the scopolamine-induced amnesia and that AT2 receptors contribute to the beneficial effects of candesartan. Theses finding corroborated the number of clinical studies that RAS inhibition in hypertensive patients could be neuroprotective.

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“…Few reports on Commiphora genus is previously reported which have a close interaction with Alzheimer's disease. Commiphora wightii had ameliorated the scopolamine and streptozotocin-induced memory deficits in mice 34 . Sesquiterpenes isolated from the resins of Commiphora myrrha were reported for its neuroprotective effects 35 .…”

Section: Discussionmentioning

confidence: 95%

Commiphora Berryi Ameliorating Effect on Scopolamine-Induced Memory Impairments in Mice

Dhivya¹,

Selvamani²,

Latha³

2017

Int. Res. J. Pharm.

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In the present study, we studied the effects of the ethanol extract of Commiphora berryi bark on drug-induced learning and memory-impaired mice using Y-maze task and passive avoidance task. On pretreatment with the ethanol extract of Commiphora berryi at 100mg/Kg p.o significantly ameliorated scopolamine-induced cognitive impairments which were revealed by the reversal in the reduction of spontaneous alteration in the Y -maze task and by significant improvement in latency time in passive avoidance task. This confirms the presence of bioactive phytoconstituents in Commiphora berryi which could be useful to decline the cognitive deficits in memory-impaired mice.

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Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice

Cited by 101 publications

References 30 publications

Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats

Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats

Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function

Commiphora Berryi Ameliorating Effect on Scopolamine-Induced Memory Impairments in Mice

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