Natural and Synthetic Chromenes, Fused Chromenes, and Versatility of Dihydrobenzo[h]chromenes in Organic Synthesis

Abstract

as a visiting professor under Alexander von Humboldt Fellowship. His research contributions are in the field of medicinal as well as synthetic organic chemistry by developing the chemistry of 2-pyranone.

The study of metal-free and palladium-catalysed synthesis of benzochromenes via direct C–H arylation using unactivated aryl benzyl ethers derived from essential oils as raw materials

“…1,2 This heteroaromatic system is present in many natural products, such as pulchrol 1 and pulchral 2, both isolated from the plant Bourreria pulchra and possessing interesting antiprotozoal activities towards Leishmania mexicana and Trypanosoma cruzi, especially 1.…”

Synthesis and Antimicrobial Activity of Novel 3,7-Disubstituted 2H-1- Benzopyran-2-Ones

“…2H-1-benzopyran-2-one (Coumarin) is an important oxygen heterocyclic scaffold, widely distributed throughout the plant kingdom [1][2][3] and exhibited a wide range of biological activities [4] such as anticancer [5,6], anti-inflammatory [7], antioxidant [8], anti-tubercular [9], antihyperglycemic [10,11], MAO-B inhibitory anticoagulation [12,13] antimicrobial [14][15][16][17], (antifungal and antimicrobial) etc. It has been reported that 7-amino substituted coumarins plays a significant role as biologically active compounds in various diseases and as substrates for P-450 isozymes [18] and 7-amino 2H-1-benzopyran-2-one derivatives isolated from Loeselia Mexicana, Petroselinum crispum, Ruta graveolens and Aesculus pavia exhibited significant antimicrobial activity [19].…”

An easy synthesis of diversely functionalized 2H-chromenes and amido amines by an enol-Ugi reaction

“…1,2 In addition, many 2H-chromenes have utility as photochromic materials [3][4][5][6] and as intermediates in the synthesis of more complex polycyclic heterocycles. [7][8][9][10][11] These important applications have stimulated the development of diverse synthetic approaches to 2H-chromenes; however, new efficient strategies leading to novel substitution patterns are still required.…”