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The curcumin loaded PMMA-AA/ZnO nanocomposite potentially inhibited the growth of AGS cancer tumour in male Swiss albino mouse, which showed a promising targeted cancer therapy. Interestingly the given bio-nanocomposite was rapidly cleared from the organs with negligible exhibition of toxicity. From the obtained results it is understood that the apoptosis has been occurred through mitochondrial disruption-mediated pathway. Also these nanomaterials could efficiently hinder the Go/G1 transition along with cycle progression at S-phase transition due to the radiation-induced DNA damage. These findings declared that the auspicious candidate, curcumin could be successfully delivered into the target by the polymer encapsulated ZnO NPs and exhibited a potent activity against gastric cancer cells at molecular and cellular levels as well as cell proliferation in a panel of tumour cells.

Bioactive carboxyamide ligated Cu II (1), Co II (2) and Ni II (3) complexes have been synthesized and characterized using various physico-chemical techniques. In particular, the occurred slightly distorted square planar geometry in complex 1 was confirmed by single X-ray crystal structure. Their (1, 2 and 3) potential interactions with herring sperm DNA (HS-DNA) have been investigated using spectral and electrochemical techniques. All these studies suggested that the complex 1 could partially penetrated in the sugar phosphate backbone and stacked in between the DNA base pairs, while the other complexes 2 & 3 could bound only on the grooves of HS-DNA due to their bi-ligated architecture around the metal centre. The potent cytotoxicity of L and its complexes 1-3 was also evaluated against AGS human gastric cancer cells. Hoechst 33342/PI double staining images revealed that the complexes significantly induced cell death through apoptosis. In vivo administration of complex 1 remarkably inhibits the tumor growth in male Swiss albino mice, moreover it did not show any hepatotoxicity in mice. All these observed results suggested that these complexes may utilized as good conventional therapeutic agents in the near feature after a series of biological assessments.

One of the greatest benefits of nanomedicine elucidated to date includes the non-invasive tracking and monitoring of living organisms by the selective uptake of harmless metallic nanoparticles. Several nanoscale probes have been employed for biomolecular imaging. Among them, fluorescent nanoscale silicon materials have been recently established with a strong and safe potential for bioimaging and biosensing applications due to their bright fluorescence coupled with strong photostability, biocompatibility and negligible toxicity. Herein, we developed high-quality silicon nanomaterials (4–5 nm; SiNPs) as biological fluorescent probes for bioimaging of living organisms through an easy aquatic synthesis method with a quantum yield of ∼8%. In this regard, we report that the presently synthesized SiNPs-based sensors/probes are attractive materials for solvent-based fluorescence measurements and are biocompatible, non-toxic, highly photo-stable and pH stable. Most importantly, their fluorescence lifetime is much longer than that of native probes in living cells. Thus, these presently formulated SiNPs are improved fluorescent probes for in vivo biological imaging in zebra fish embryos as well as numerous other living organisms and, thus, should be further studied.