Enhancing the anti-gastric cancer activity of curcumin with biocompatible and pH sensitive PMMA-AA/ZnO nanoparticles

Dhivya, Raman; Ranjani, Jothi; Rajendhran, Jeyaprakash; Mayandi, J.; Annaraj, Jamespandi

doi:10.1016/j.msec.2017.08.058

Cited by 58 publications

(30 citation statements)

References 41 publications

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“…In order to improve the solubility and bioavailability of curcumin, Dhivya et al fabricated two novel copolymer-encapsulated ZnO NPs for carrying curcumin, Cur/PMMA-PEG/ZnO NPs, and Cur/PMMA-AA/ZnO NPs nanocomposites [ 54 , 55 ]. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8.…”

Section: Biomedical Applications Of Zno Nanoparticlesmentioning

confidence: 99%

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

Jiang

Cai

2018

Bioinorganic Chemistry and Applications

825

463

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Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger excess reactive oxygen species (ROS) production, release zinc ions, and induce cell apoptosis. In addition, zinc is well known to keep the structural integrity of insulin. So, ZnO NPs also have been effectively developed for antidiabetic treatment. Moreover, ZnO NPs show excellent luminescent properties and have turned them into one of the main candidates for bioimaging. Here, we summarize the synthesis and recent advances of ZnO NPs in the biomedical fields, which will be helpful for facilitating their future research progress and focusing on biomedical fields.

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Section: Biomedical Applications Of Zno Nanoparticlesmentioning

confidence: 99%

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

Jiang

Cai

2018

Bioinorganic Chemistry and Applications

825

463

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“…This study revealed the potential application of curcumin magnetic nanoparticles to visualize amyloid plaques in Alzheimer’s disease [ 67 ]. Curcumin loaded zinc oxide nanoparticles encapsulated with a co-polymer were successfully synthesized, and their anticancer activity showed excellent cytotoxicity effects in AGS gastric cancer cells [ 68 ]. In vitro and in vivo studies showed that curcumin encapsulated PLGA nanoparticles showed effective targeting and growth inhibition of prostate cancer cells [ 69 ].…”

Section: Recent Advances Of Nanocurcumin In Aging-associated Diseamentioning

confidence: 99%

Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases

2018

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Curcumin, a low molecular weight, lipophilic, major yellow natural polyphenolic, and the most well-known plant-derived compound, is extracted from the rhizomes of the turmeric (Curcuma longa) plant. Curcumin has been demonstrated as an effective therapeutic agent in traditional medicine for the treatment and prevention of different diseases. It has also shown a wide range of biological and pharmacological effects in drug delivery, and has actively been used for the treatment of aging-associated diseases, including cardiovascular diseases, atherosclerosis, neurodegenerative diseases, cancer, rheumatoid arthritis, ocular diseases, osteoporosis, diabetes, hypertension, chronic kidney diseases, chronic inflammation and infection. The functional application and therapeutic potential of curcumin in the treatment of aging-associated diseases is well documented in the literature. This review article focuses mainly on the potential role of plant-derived natural compounds such as curcumin, their mechanism of action and recent advances in the treatment of aging-associated diseases. Moreover, the review briefly recaps on the recent progress made in the preparation of nanocurcumins and their therapeutic potential in clinical research for the treatment of aging-associated diseases.

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“…Curcumin, the wellknown natural medicinal material demonstrated activity against a wide range of solid tumors (e.g., colon, lung, pancreatic, breast, bladder, and ovarian cancers) [14], was selected as a drug model. Earlier we have reported the in-vitro evaluations of Cur/PMMA-AA/ZnO NPs [15], while its in-vivo evaluations have been carried out in a detailed manner and discussed in this present work. The loss of mitochondrial membrane potential (MMP) is a direct indication of the apoptosis, therefore it is necessary to evaluate the efficiency of Cur/PMMA-AA/ZnO NPs in the loss of MMP in detail.…”

Section: Methodsmentioning

confidence: 99%

pH Triggered Curcumin Release from PMMA-AA Coated ZnO Nanoparticles for Excellent Anti-Gastric Cancer Therapy

Dhivya¹,

Ranjani²,

Rajendhran³

et al. 2018

J Material Sci Eng

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The curcumin loaded PMMA-AA/ZnO nanocomposite potentially inhibited the growth of AGS cancer tumour in male Swiss albino mouse, which showed a promising targeted cancer therapy. Interestingly the given bio-nanocomposite was rapidly cleared from the organs with negligible exhibition of toxicity. From the obtained results it is understood that the apoptosis has been occurred through mitochondrial disruption-mediated pathway. Also these nanomaterials could efficiently hinder the Go/G1 transition along with cycle progression at S-phase transition due to the radiation-induced DNA damage. These findings declared that the auspicious candidate, curcumin could be successfully delivered into the target by the polymer encapsulated ZnO NPs and exhibited a potent activity against gastric cancer cells at molecular and cellular levels as well as cell proliferation in a panel of tumour cells.

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Enhancing the anti-gastric cancer activity of curcumin with biocompatible and pH sensitive PMMA-AA/ZnO nanoparticles

Cited by 58 publications

References 41 publications

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases

pH Triggered Curcumin Release from PMMA-AA Coated ZnO Nanoparticles for Excellent Anti-Gastric Cancer Therapy

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