Biocompatible curcumin loaded PMMA-PEG/ZnO nanocomposite induce apoptosis and cytotoxicity in human gastric cancer cells

Dhivya, Raman; Ranjani, Jothi; Bowen, Patrick K.; Rajendhran, Jeyaprakash; Mayandi, J.; Annaraj, Jamespandi

doi:10.1016/j.msec.2017.05.128

Cited by 78 publications

(31 citation statements)

References 34 publications

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“…In order to improve the solubility and bioavailability of curcumin, Dhivya et al fabricated two novel copolymer-encapsulated ZnO NPs for carrying curcumin, Cur/PMMA-PEG/ZnO NPs, and Cur/PMMA-AA/ZnO NPs nanocomposites [ 54 , 55 ]. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8.…”

Section: Biomedical Applications Of Zno Nanoparticlesmentioning

confidence: 99%

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

Jiang

Cai

2018

Bioinorganic Chemistry and Applications

888

463

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Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger excess reactive oxygen species (ROS) production, release zinc ions, and induce cell apoptosis. In addition, zinc is well known to keep the structural integrity of insulin. So, ZnO NPs also have been effectively developed for antidiabetic treatment. Moreover, ZnO NPs show excellent luminescent properties and have turned them into one of the main candidates for bioimaging. Here, we summarize the synthesis and recent advances of ZnO NPs in the biomedical fields, which will be helpful for facilitating their future research progress and focusing on biomedical fields.

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Section: Biomedical Applications Of Zno Nanoparticlesmentioning

confidence: 99%

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

Jiang

Cai

2018

Bioinorganic Chemistry and Applications

888

463

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“…Dhivya et al. have observed similar results with PMMA‐PEG‐ZnO nanoparticles . The high levels of CUR released from micelles in the tumor microenvironment (pH 5.0) and the minimal amount released at pH 7.4 (colonic pH) indicates that these micelles will only release its content once inside tumor cells, and otherwise remains encapsulated within the micellar structure.…”

Section: Resultsmentioning

confidence: 76%

Oral Delivery of Multicompartment Nanomedicines for Colorectal Cancer Therapeutics: Combining Loco‐Regional Delivery with Cell‐Target Specificity

Akhter

Simpson

Fletcher

et al. 2019

Advanced Therapeutics

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Nanomaterials for targeted delivery of chemotherapeutics have received significant attention owing to their potential to enhance the accumulation of therapeutics in diseased tissue. However, in diseases with poor vascularization, such as colorectal cancer (CRC), intravenously injected materials have reduced access to the site of interest. To overcome this challenge, oral administration of targeted nanomedicines is highly desirable. Here, a multicomponent drug delivery system incorporating a degradable alginate microcapsule, formulated to encapsulate micelles targeted to the CD44 receptor is presented. Functional micelles are generated by coupling hyaluronic acid (to target CD44 receptor) to block copolymers of poly(ethylene glycol) monomethyl ether methacrylate and poly(methyl methacrylate). When encapsulated into alginate microcapsules, these micelles form the basis of a novel oral delivery system that offers protection from degradative compartments of the gastrointestinal tract (GIT) and regio‐specific release. The microcapsules demonstrate desirable site‐specific degradation properties in an orthotopic CRC xenograft mouse model, yielding enhanced accumulation of micelles within CD44+ colorectal tumors. The results illustrate that such materials successfully navigate the GIT, regio‐specifically release targeted micelles at the tumor site, and consequently accomplish enhanced accumulation within tumor tissue. Such multi‐component nanomaterials offer a promising means for addressing challenges in treating CRC and difficult to treat diseases.

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“…Apoptosis is a process of programmed cell death that occurs in multicellular organisms and inhibition of apoptosis can result in a number of cancers . Apoptosis is generally characterized by phosphatidylserine externalization, depolarization of mitochondrial membrane, caspase‐3 activation and DNA fragmentation .…”

Section: Discussionmentioning

confidence: 99%

HOXC13 promotes proliferation of esophageal squamous cell carcinoma via repressing transcription ofCASP3

et al. 2017

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Esophageal squamous cell carcinoma (ESCC), the dominant subtype of esophageal cancer, is one of the most common digestive tumors worldwide. In this study, we confirmed that HOXC13, a member of the homeobox HOXC gene family, was significantly upregulated in ESCC and its overexpression was associated with poorer clinical characteristics and worse prognosis. Moreover, knockdown of HOXC13 inhibited proliferation and induced apoptosis of ESCC through upregulating CASP3. ChIP analysis revealed that HOXC13 repressed transcription of CASP3 through directly targeting the promotor region of CASP3. We also found that miR‐503 downregulated HOXC13, by directly targeting its 3′UTR, and inhibited proliferation of ESCC. In conclusion, our study demonstrates that HOXC13, which is directly targeted by miR‐503, promotes proliferation and inhibits apoptosis of ESCC through repressing transcription of CASP3.

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Biocompatible curcumin loaded PMMA-PEG/ZnO nanocomposite induce apoptosis and cytotoxicity in human gastric cancer cells

Cited by 78 publications

References 34 publications

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

Oral Delivery of Multicompartment Nanomedicines for Colorectal Cancer Therapeutics: Combining Loco‐Regional Delivery with Cell‐Target Specificity

HOXC13 promotes proliferation of esophageal squamous cell carcinoma via repressing transcription ofCASP3

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