Role of Nanocurcumin as a Surface Modifying Agent with Excellent Preventive Effect on Device-Related CoNS Infections

Soumya, K. R.; Jishma, P.; Dhivya, Raman; Annaraj, Jamespandi; Sugathan, Sheela; Mathew, Jyothis; Radhakrishnan, E. K.

doi:10.1007/s40011-019-01075-z

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…On the other hand, figure 7 showed that all tested rubbers ( natural and synthetic) had no activity towards Candida albicans fungi. These results are in accordance with other works [23][24].…”

Section: 2 Antimicrobial Activity Resultssupporting

confidence: 94%

Safety rubber vulcanizates containing natural product for toys industry

et al. 2022

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The present work aims to prepare nanocurcum and incorporate it into rubber formulations through the ordinary rubber mixer, and study the rheological characteristics of the prepared compounded rubber. Also, evaluate the physicomechanical properties of the vulcanizates as well as the cytotoxicity and the antimicrobial effects. The innovative product would open the door for advanced application in the field of antibacterial/antimicrobial children's toys and infant dummies. Natural and some synthetic rubber, including Ethylene propylene diene monomer (EPDM) and styrene butadiene rubber (SBR), were investigated for this study. Rubber and their ingredients as well as natural product applied antimicrobial agents such as nanocurcum were mixed in the ordinary rubber mixer. The rheological characteristics of compounded rubber were measured and the curing time was determined. The compounded rubber was vulcanized in a hydraulic press at a specified temperature and estimated cure time. The physicomechanical properties were evaluated. Additionally, the scanning electron micrographs (SEM) illustrated surface homogeneity of vulcanizate sample that demonstrate appropriate compatibility and dispersion of the material inside rubber chains. The rheological characteristics of natural rubber vulcanizates were superb and show no significant change in the presence of assessed natural product drug (nanocrucum). Moreover, the physicomechanical properties such as tensile strength and elongation were increased in the presence of nanocrucum depending on its nature and concentration. The same observation was obtained for styrene butadiene rubber and EPDM vulcanizates under investigation. On one hand, the cytotoxicity of the prepared vulcanizates towards the human normal retina cell line (RPI-1) indicated the safety properties of the prepared vulcanizates. On the other hand, the as-prepared nanocurcum rubber vulcanizates manifested moderate antagonistic activities against the examined bacteria and fungi strains and a significant inhibition in their growth was indicated.

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Section: 2 Antimicrobial Activity Resultssupporting

confidence: 94%

Safety rubber vulcanizates containing natural product for toys industry

et al. 2022

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“…Another study by Sharifi et al [ 51 ] confirmed the effectiveness of nanocurcumin against E. coli , S. aureus, S. pneumonia , and Shigella dysenteriae, which was better than that of the commercial antibiotic amoxicillin. Further, nanocurcumin prevented the formation of biofilm and inhibited the coagulase-negative Staphylococcus (CoNS) colonization in nasogastric polyvinyl chloride (PVC) tubes [ 52 ]. The antibacterial ability of ZnO nanoparticles has been studied against B. subtilis , S. aureus , P. aeruginosa, C. jejuni , and E. coli .…”

Section: Resultsmentioning

confidence: 99%

Inhibition of Staphylococcus aureus α‐Hemolysin Production Using Nanocurcumin Capped Au@ZnO Nanocomposite

Jabir

Rashid

Nayef

et al. 2022

Bioinorganic Chemistry and Applications

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Nanoparticles of gold with zinc oxide (Au@ZnO NPs) were prepared by laser ablation and then capped with curcumin nanoparticles (Cur-Au@ZnO NPs). The synthesized NPs were characterized using different techniques, including transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), UV-visible spectroscopy, and X-ray diffraction. In addition, the ability of NPs as a promising antibacterial agent was tested against Staphylococcus aureus through the agar well diffusion method and AO/EtBr staining assay. The results showed that the prepared nanoparticles (Cur-Au@ZnO) served as an antibacterial agent and can destroy the bacterial cells by losing the cell wall integrity and penetrating the cytoplasmic membrane. Moreover, the findings confirmed the role of the formed NPs in attenuation of the adherence and invasion of S. aureus to rat embryonic fibroblast (REF) cells. Furthermore, the activity of Cur-Au@ZnO NPs against the S. aureus α-hemolysin toxin was evaluated using the western blot technique, using human alveolar epithelial cells (A549), and through histopathology examination in a mouse model. In conclusion, the built Cur-Au@ZnO NPs can be used as a potential antibacterial agent and an inhibitor of α-hemolysin toxin secreted by S. aureus. These NPs may offer a new strategy in combating pathogen infections and in the future for biomedical and pharmaceutical applications.

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“…The tube is passed through the nasogastric route. In a study by [ 91 ], it has been focused that these tubes are susceptible to bio-film forming bacteria such as Staphylococcus sp. per day.…”

Section: Uses Of Nanocurcuminmentioning

confidence: 99%

“…These bacteria start colonizing on the surface of the catheter, especially coagulase-negative Staphylococci (CoNS), and its surface attachment to abiotic or biotic surfaces occurs, which leads to further maturation and accumulation of the bio-film, and thus results in increased resistance to antibacterial agents. The two CoNS, which specifically exert such characteristics, are S. haemolyticus and S. epidermidis [ 91 ].…”

Section: Uses Of Nanocurcuminmentioning

confidence: 99%

“…Furthermore, a microbiological test delineated the efficiency of nanocurcumin against bacterial species such as Escherichia coli, Staphylococcus aureus, Shigella dysenteriae , and Streptococcus pneumonia was observed to be higher in comparison to amoxicillin, a commercial antibiotic [ 95 ]. On the other hand, an article by [ 91 ] stated that nanocurcumin is found to act as an excellent surface protecting agent and thereby inhibits the bio-film formation and CoNS colonization in nasogastric polyvinyl chloride (PVC) tubes. Thus, it is considered as useful antibacterial and anti-bio-film forming agents that can be applied to reduce and prevent medical device related infections.…”

Section: Uses Of Nanocurcuminmentioning

confidence: 99%

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Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets

et al. 2021

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Curcuma longa is very well-known medicinal plant not only in the Asian hemisphere but also known across the globe for its therapeutic and medicinal benefits. The active moiety of Curcuma longa is curcumin and has gained importance in various treatments of various disorders such as antibacterial, antiprotozoal, cancer, obesity, diabetics and wound healing applications. Several techniques had been exploited as reported by researchers for increasing the therapeutic potential and its pharmacological activity. Here, the dictum is the new room for the development of physicochemical, as well as biological, studies for the efficacy in target specificity. Here, we discussed nanoformulation techniques, which lend support to upgrade the characters to the curcumin such as enhancing bioavailability, increasing solubility, modifying metabolisms, and target specificity, prolonged circulation, enhanced permeation. Our manuscript tried to seek the attention of the researcher by framing some solutions of some existing troubleshoots of this bioactive component for enhanced applications and making the formulations feasible at an industrial production scale. This manuscript focuses on recent inventions as well, which can further be implemented at the community level.

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Role of Nanocurcumin as a Surface Modifying Agent with Excellent Preventive Effect on Device-Related CoNS Infections

Cited by 7 publications

References 20 publications

Safety rubber vulcanizates containing natural product for toys industry

Safety rubber vulcanizates containing natural product for toys industry

Inhibition of Staphylococcus aureus α‐Hemolysin Production Using Nanocurcumin Capped Au@ZnO Nanocomposite

Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets

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