The polymer composites based on Polyvinyl alcohol loaded with different concentrations of commercial curcumin were prepared to be applied forcontrolled release drug delivery system to overcome the growth promotion of tumor cells. The prepared composites were subjected to drug release in aqueous media at room temperature. It was found that the amount of the released curcumin changed according to different pH media and the concentration of the loaded drug onto the polymer carrier. The diffusion coefficient of the released curcumin from the prepared composites was found to be 2.739X10 -2 , 1.638X10 -2 , and 5.777X10 -4 in basic, acidic and neutral solution respectively according to Higuch's equation. The results of the in/vitro cytotoxic activity of the released curcumin showed sustained antiproliferative potency up to 30 % growth inhibition against the human liver cancer cell line (HEPG2) which extended to 25 days, to overcome hepatocarcinoma.
SYNOPSISComposites of styrene-butadiene rubber were prepared with three different types of lead oxide, namely, monolead oxide ( PbO) , lead dioxide ( PbOz), and red lead oxide ( Pb304).Concentrations of PbsO, ranging between 17 and 88 wt % were utilized, whereas 87 wt 7% was used for PbO and Pb02. The prepared composites were investigated for their gamma radiation shielding properties. Moreover, physical and mechanical properties, and electrical conductivity were measured for both the unirradiated and irradiated composites. The highest value obtained for the linear absorption coefficient was 0.424 cm-' for 88% Pb304.
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