pH Responsive Curcumin/ ZnO Nanocomposite For Drug Delivery

Dhivya, Raman; Annaraj, Marichamy Rajasekaran;Jamespandi; Ranjani, Jothi; Rajendhran, Jeyaprakash

doi:10.5185/amlett.2015.5766

Cited by 32 publications

(33 citation statements)

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“…Curcumin as an antioxidant molecule has the potential to inhibit cancer cell proliferation . Dhivya et al . conjugated nanocurcumin to ZnO nanoparticles and tested the antimicrobial and anticancer activity of nanocurcumin and ZnO nanoparticle nanocomposites.…”

Section: Nanocomposites As Efficient Drug Delivery Systems To Addressmentioning

confidence: 99%

“…conjugated nanocurcumin to ZnO nanoparticles and tested the antimicrobial and anticancer activity of nanocurcumin and ZnO nanoparticle nanocomposites. They reported that nanocurcumin‐ZnO NP nanocomposite of 53 nm size has the potential to inhibit the proliferation of the gastric cancer cell lines due to enhanced apoptosis of the cancerous cell lines, suggesting that nanocomposites can be effective drug carriers against gastric cancer cell lines (Table ) . The nanocomposites of curcumin and ZnO NP have enhanced aqueous‐phase solubility that resulted in improved bioavailability of curcumin that effectively counter the abnormal proliferation gastric cancer cells.…”

Section: Nanocomposites As Efficient Drug Delivery Systems To Addressmentioning

confidence: 99%

“…Nanoparticle synthesis using plant extracts and microorganisms has been suggested as possible eco‐friendly alternatives to chemical and physical methods . Metal oxide nanoparticles such as ZnO, MgO, TiO 2 , SiO 2 , CuO 2 by themselves have a very good antimicrobial activity . ZnO NP has been reported to have antidiabetic and anticancer effects .…”

Section: Nanocomposites As Efficient Drug Delivery Systems To Addressmentioning

confidence: 99%

“…Curcumin when used in combination with antibiotic reduces the minimum inhibitory concentration (MIC) values of antibiotics due to synergistic mechanism and inhibited the growth of methicillin‐resistant Staphylococcus aureus proposing the development of new combination of antibiotics against MRSA infection . The antimicrobial activity of curcumin can be further enhanced by conjugation of curcumin with metal oxide nanoparticles such as ZnO, MgO, TiO 2 , SiO 2 , CuO 2, which are themselves very good antimicrobial agents . Curcumin has the potential to cure skin diseases such as psoriasis and scleroderma by inhibiting the phosphorylase kinase activity and TGF‐β‐mediated phosphorylation of SMAD2, respectively.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Curcumin as potential therapeutic natural product: a nanobiotechnological perspective

Shome

Talukdar

Choudhury

et al. 2016

Journal of Pharmacy and Pharmacology

141

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Objectives Nanotechnology-based drug delivery systems can resolve the poor bioavailability issue allied with curcumin. The therapeutic potential of curcumin can be enhanced by making nanocomposite preparation of curcumin with metal oxide nanoparticles, poly lactic-co-glycolic acid (PLGA) nanoparticles and solid lipid nanoparticles that increases its bioavailability in the tissue. Key findings Curcumin has manifold therapeutic effects which include antidiabetic, antihypertensive, anticancer, anti-inflammatory and antimicrobial properties. Curcumin can inhibit diabetes, heavy metal and stress-induced hypertension with its antioxidant, chelating and inhibitory effects on the pathways that lead to hypertension. Curcumin is an anticancer agent that can prevent abnormal cell proliferation. Nanocurcumin is an improved form of curcumin with enhanced therapeutic properties due to improved delivery to the diseased tissue, better internalization and reduced systemic elimination. Summary Curcumin has multiple pharmacologic effects, but its poor bioavailability reduces its therapeutic effects. By conjugating curcumin to metal oxide nanoparticles or encapsulation in lipid nanoparticles, dendrimers, nanogels and polymeric nanoparticles, the water solubility and bioavailability of curcumin can be improved and thus increase its pharmacological effectiveness.

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Section: Nanocomposites As Efficient Drug Delivery Systems To Addressmentioning

confidence: 99%

Section: Nanocomposites As Efficient Drug Delivery Systems To Addressmentioning

confidence: 99%

Section: Nanocomposites As Efficient Drug Delivery Systems To Addressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Curcumin as potential therapeutic natural product: a nanobiotechnological perspective

Shome

Talukdar

Choudhury

et al. 2016

Journal of Pharmacy and Pharmacology

141

View full text Add to dashboard Cite

show abstract

“…Curcumin, the wellknown natural medicinal material demonstrated activity against a wide range of solid tumors (e.g., colon, lung, pancreatic, breast, bladder, and ovarian cancers) [14], was selected as a drug model. Earlier we have reported the in-vitro evaluations of Cur/PMMA-AA/ZnO NPs [15], while its in-vivo evaluations have been carried out in a detailed manner and discussed in this present work.…”

Section: Methodsmentioning

confidence: 99%

pH Triggered Curcumin Release from PMMA-AA Coated ZnO Nanoparticles for Excellent Anti-Gastric Cancer Therapy

Dhivya¹,

Ranjani²,

Rajendhran³

et al. 2018

J Material Sci Eng

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The curcumin loaded PMMA-AA/ZnO nanocomposite potentially inhibited the growth of AGS cancer tumour in male Swiss albino mouse, which showed a promising targeted cancer therapy. Interestingly the given bio-nanocomposite was rapidly cleared from the organs with negligible exhibition of toxicity. From the obtained results it is understood that the apoptosis has been occurred through mitochondrial disruption-mediated pathway. Also these nanomaterials could efficiently hinder the Go/G1 transition along with cycle progression at S-phase transition due to the radiation-induced DNA damage. These findings declared that the auspicious candidate, curcumin could be successfully delivered into the target by the polymer encapsulated ZnO NPs and exhibited a potent activity against gastric cancer cells at molecular and cellular levels as well as cell proliferation in a panel of tumour cells.

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