The Objective of the present study was to develop a simple, reproducible and economical spectrophotometric method for simultaneous determination of Ciprofloxacin and Naproxen. Both Drugs obey Beer's law in the range of 1-5µg/ml concentration. The Standard curve of Ciprofloxacin and Naproxen in the media of 0.1N HCl, Distilled water and Phosphate buffer are obtained by plotting absorbance versus concentration where calibration curve was found to be linear (R 2 >0.99) with optimum value of standard error for the entire analytical medium used. The plot of the residuals was normally distributed around the regression line, which reflects the accuracy of the method. For simultaneous determination of Ciprofloxacin and Naproxen, the linear plot was found in the media of distilled water and 0.1N HCl acid. The maximum absorbance was found in the media of distilled water for Ciprofloxacin at wavelength 278nm and for Naproxen at 228nm. The calibration curve was to be linear for Ciprofloxacin as R 2 >0.99 and for Naproxen as R 2 >0.99.The maximum absorbance was found in the media of 0.1N HCl for Ciprofloxacin at wavelength 277nm and for Naproxen at 228nm. The calibration curve was to be linear for Ciprofloxacin as R 2 >0.98 and for Naproxen as R 2 >0.99.
A new, simple, specific, sensitive, rapid and economical procedure has been developed for determination of Nitroglycerin in its dosage form. The objective of this validation of an analytical procedure is to demonstrate that the drug Nitroglycerin is suitable for its intended purpose. The analytical method development recommends the quality, purity and specificity of the drug Nitroglycerin tablet form during the manufacturing process and hence the standard of the drug may not vary, which produce the desirable therapeutic effect. The method is based on the ultraviolet absorbance maxima of the above drug at 210nm. The drug obeyed Beer's law in the concentration range of 15μg/ml in methanol. The proposed methods were successfully applied for the determination of drug in commercial tablet preparations. The results of the analysis have been validated statistically and by recovery studies. Key Words: Nitroglycerin; ultraviolet spectroscopy; analysis; dosage form; validation.DOI: http://dx.doi.org/10.3329/icpj.v1i1.9217 International Current Pharmaceutical Journal 2011, 1(1): 1-5
Diabetes mellitus is a chronic ailment that impairs the production of or response to insulin, a hormone that helps to convert food into energy. Its complications are responsible for excess morbidity and mortality, loss of independence and reduce quality of life. Among the major cause of disablement and early death are ischemic heart disease, retinopathy, nephropathy, peripheral vascular disease and neuropathy. Insulin replacement therapy has been used in the clinical management of diabetes mellitus for more than 85 years. As subcutaneous injection is a painful episode so various approaches like transdermal, pulmonary, intranasal, colon targeted delivery, oral delivery is tried as an alternative way. Among them oral delivery is the challenging one because insulin cannot administered orally due to rapid enzymatic digestion in stomach. For oral delivery various technology, formulation and various modification approaches are going on. It is high time to invent an acceptable non-invasive insulin delivery for the diabetes to improve patient compliance and decrease the morbidity.Key Words: Insulin; Approaches; Obstacles; Route of administration; Non-invasive.DOI: http://dx.doi.org/10.3329/icpj.v1i2.9447International Current Pharmaceutical Journal 2012, 1(2): 32-42
Background: Vitamin D deficiency is very common in Bangladesh. However, there is scanty of literature available about the knowledge of calcium and vitamin D in 16-18 years old adolescents. The present study has been conducted to determine whether a lack of knowledge exists in this age group about these nutrients and to find out the correlation between students' living in urban or rural areas. Methods: We conducted a cross sectional survey in 2992 students living in urban (62.6%) and rural (37.4%) areas aged between 16-18 years. We followed a 2 step sampling technique. 6 colleges from both urban and rural areas were selected by convenience of the interviewers and then required sample size was calculated from the number of students of each college. The students filled up a questionnaire after a detailed briefing about the study by the interviewer. Result: We found that many of the students, both from urban and rural settings have lack of knowledge and awareness of calcium and vitamin D. Our data suggest that though the rural students are less familiar with vitamin D (p<0.001) and osteoporosis (p=0.0056) than urban students, they exercise a healthy diet in terms of milk consumption (p<0.0001) and engage themselves more in outdoor activities, spend more time in sunlight (p<0.0001) than the urban students. Thus the rural students may require less supplemental support of calcium and/or vitamin D than the urban students (p<0.0001). Conclusion: Urban students are more familiar with the nutrients than the rural students but rural students' lifestyle, diet and food habit may allow them to get a healthier nutritional support and thus to have a better nutritional health than urban students.
Dalbergia sissoo plant, often known as the Bangladesh Shishu, is a member of the Fabaceae family. It widespread in Bangladesh, including Sylhet, Ranirhat, Isamoti, and Chittagong. It is also found in Afghanistan, Pakistan, India, and Nepal. This plant has been used to treat leukoderma, diarrhea, dyspepsia, ulcers, stomach disorders, itching, syphilis, scabies. This plant's extract comprised terpenoids, alkaloids, glycosides, flavanols, tannins, saponins, and glycosides. All segments of Dalbergia sissoo are analgesic, anti-inflammatory, anthelmintic, antidiarrheal, molluscicidal, antinociceptive, antioxidant, antiulcer, antimicrobial, antidiabetic, osteogenic, antispermatogenic, antitemite and neuroprotective activities. The accessible information was acquired from research articles using a keyword search in Google Scholar, Pub med, Science direct, Springer Link, Wiley and Sci-Hub. The foregoing criteria selected 35 suitable articles from 2000 to 2022 for this study. This research examines Dalbergia sissoo's botanical traits, therapeutic value, and bioactive compounds. This analysis will aid future scientific research as pharmacologists must gather and identify data.
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