BackgroundCalcium and vitamin D are two important micronutrients required for maintaining proper bone health. Previous works intended to determine the status of these micronutrients in local population have reported that the people in Bangladesh are at high risk of calcium insufficiency and hypovitaminosis D related health complications. Lack of awareness and insufficient knowledge of the essentiality of these two nutrients are assumed to cause this problem in Bangladesh. The present study was designed and conducted to establish a basic understanding on the level of gap of knowledge and awareness among pharmacy students at undergraduate level in Bangladesh.FindingsA total of 713 students of Bachelor of Pharmacy course participated in the study. The students were asked about basic idea related to calcium and vitamin D and the disorders due to their deficiency, name of common foods containing calcium and vitamin D, their perception regarding the essentiality of the said nutrients etc. It was found that most of the students were familiar with the importance of calcium (98.9%) and vitamin D (99.3%) in bone health. 82.2% students know about the term osteoporosis. Unfortunately, 10.7% and 18.8% students failed to mention at least one food that is rich in calcium and vitamin D, respectively. Most of the students got familiar about the nutrients from their teachers (48.9%) and textbooks (32.8%).ConclusionBeing a student of pharmacy, the students should have more comprehensive knowledge about calcium and vitamin D. The present study indicates that the pharmacy students have lack of knowledge about calcium and vitamin D and thus it can be clearly predicted that the condition of general people may be worse.
The Objective of the present study was to develop a simple, reproducible and economical spectrophotometric method for simultaneous determination of Ciprofloxacin and Naproxen. Both Drugs obey Beer's law in the range of 1-5µg/ml concentration. The Standard curve of Ciprofloxacin and Naproxen in the media of 0.1N HCl, Distilled water and Phosphate buffer are obtained by plotting absorbance versus concentration where calibration curve was found to be linear (R 2 >0.99) with optimum value of standard error for the entire analytical medium used. The plot of the residuals was normally distributed around the regression line, which reflects the accuracy of the method. For simultaneous determination of Ciprofloxacin and Naproxen, the linear plot was found in the media of distilled water and 0.1N HCl acid. The maximum absorbance was found in the media of distilled water for Ciprofloxacin at wavelength 278nm and for Naproxen at 228nm. The calibration curve was to be linear for Ciprofloxacin as R 2 >0.99 and for Naproxen as R 2 >0.99.The maximum absorbance was found in the media of 0.1N HCl for Ciprofloxacin at wavelength 277nm and for Naproxen at 228nm. The calibration curve was to be linear for Ciprofloxacin as R 2 >0.98 and for Naproxen as R 2 >0.99.
The purpose of this study was to prepare and characterize solid dispersions of the NSAID Ibuprofen with HPMC, HPC, icing sugar, dextrose, mannitol and lactose with the intention of improving its dissolution properties. The solid dispersions were prepared by the fusion method. Evaluation of the properties of the dispersions was performed using dissolution studies. The results obtained showed that the rate of dissolution of Ibuprofen was considerably improved when formulated in solid dispersions with HPMC and HPC. Solid dispersions with icing sugar, dextrose, mannitol and lactose showed drug retarding capability which may trigger more research in the intension of exploiting this feature to prepare sustained release dosage form.
A new, simple, specific, sensitive, rapid and economical procedure has been developed for determination of Nitroglycerin in its dosage form. The objective of this validation of an analytical procedure is to demonstrate that the drug Nitroglycerin is suitable for its intended purpose. The analytical method development recommends the quality, purity and specificity of the drug Nitroglycerin tablet form during the manufacturing process and hence the standard of the drug may not vary, which produce the desirable therapeutic effect. The method is based on the ultraviolet absorbance maxima of the above drug at 210nm. The drug obeyed Beer's law in the concentration range of 15μg/ml in methanol. The proposed methods were successfully applied for the determination of drug in commercial tablet preparations. The results of the analysis have been validated statistically and by recovery studies. Key Words: Nitroglycerin; ultraviolet spectroscopy; analysis; dosage form; validation.DOI: http://dx.doi.org/10.3329/icpj.v1i1.9217 International Current Pharmaceutical Journal 2011, 1(1): 1-5
The purpose of this study was to prepare and characterize solid dispersions of the NSAID Ibuprofen with PEG 6000, Poloxomer 188 and Poloxomer 407 with the intention of improving its dissolution properties. The solid dispersions were prepared by the fusion method. Evaluation of the properties of the dispersions was performed using dissolution studies. The results obtained showed that the rate of dissolution of Ibuprofen was considerably improved when formulated in solid dispersions with PEG 6000 and poloxomer 188. Solid dispersions with poloxomer 407 showed drug retarding capability which may trigger more research in the intension of exploiting this feature to prepare sustained release dosage form.
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