In this work, we present a rapid, metal‐free and efficient method for thiocyanation of aromatic amines under microwave irradiation for the synthesis of aryl thiocyanates using inexpensive and nontoxic NH4SCN as thiocyanato source and K2S2O8 as an oxidant. This protocol tolerates a wide range of substituted anilines to provide the corresponding thiocyanated products in good to excellent yields. The features of this strategy include a broad substrate scope, high functional group tolerance, mild reaction conditions, and short reaction time.
A rapid, ligand/oxidant/base-free, silver carbonate-catalyzed homocoupling reaction of aryl boronic acids under microwave irradiation for the synthesis of symmetric biaryls is described here. This protocol tolerates a wide range of electron-donating, electron-withdrawing, and heterocyclic boronic acids to pro-vide the corresponding biaryl products in good to excellent yields. The features of this strategy include a wide substrate scope, mild reaction conditions, high functional group tolerance, good to excellent yields, and short reaction time.
Diaryl sulfones are known to show diverse pharmacological properties, which calls for an efficient and convenient method for their synthesis. Here, we report a Cu-catalyzed crosscoupling method for the synthesis of diaryl sulfones from ptoluenesulfonyl hydrazide and aryl boronic acids in the absence of an additional ligand. This synthesis procedure is character-ized by the use of inexpensive and readily available starting materials, mild reaction conditions, and a broad functionality tolerance. Remarkably, various diaryl sulfones have been synthesized in very short reaction times with moderate to excellent yields.
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