Alkynes are one of the most fundamental and diverse functional groups utilized in organic synthesis. Over the past few years, the development of efficient synthetic methodologies for the functionalization of alkynes has been an active area of research. A plethora of alkyne functionalization reactions have been reported in the literature to construct functionalized alkynes and alkene scaffolds, which are important building blocks in many natural products, pharmaceuticals, and key intermediates in various synthetic transformations. In this review, we describe the most recent advances in the functionalization of alkynes with an emphasis on substrate scope, limitations, regioselectivity control and applications of these reactions. This review covers the literature from 2016 to 2021.

Olefins are synthetically useful building blocks in modern organic synthesis. Direct functionalization of olefins; represent one of the most explored transformations in synthetic chemistry due to their easy availability and reactivity towards large number of reactants affording diverse range of organic compounds. In recent times, the development of new protocols for the functionalization of olefins is a growing realm. A plethora of olefin functionalization methodologies have been reported in the literature through ionic and free radical mechanisms including single electron transfer (SET) in the last two decades. This review gives an overview of mono-and difunctionalization of unactivated olefins, with an emphasis on the mechanistic details. Functionalization of Unactivated Olefins via Visible-Light Photocatalysis Iridium Photo-Catalyzed Reactions CarbofunctionalizationGlorius and co-workers reported an efficient visible-light mediated three component dicarbofunctionalization of olefins 2 using simple benzylic Katritzky salts 1 as radical precursors (Scheme 1). [8] In this protocol, abundant styrenes, electron-rich heterocycles, and benzylic amines were successfully employed to afford a number of densely functionalized 1,1-diarylalkanes. The optimal reaction conditions for this reaction are [Ir-(dtbbpy)(ppy) 2 ](PF 6 ) (1 mol%) as the photocatalyst in MeCN under irradiation with visible light for 16 h. Under the optimum [a

Heterocyclic compounds are widely present in the core structures of several natural products, pharmaceuticals and agrochemicals thus great efforts have been ascribed for their synthesis in a mild and simpler...

Over the past decade, visible-light photoredox catalysis has blossomed as a powerful strategy and offers a discrete activation mode complementary to thermal controlled reactions. Visible-light-mediated photoredox catalysis also offers exciting...

Heterocycles and carbocyclic cores are ubiquitous scaffolds in organic molecules and important components of many natural products, pharmaceuticals, agrochemicals and organic materials. Thus, developing efficient synthetic methodologies for the easy generation of carbo-and heterocycles is an important goal in synthetic chemistry. This review is mainly focused on the recent developments in the synthesis of various carbo-and heterocyclic compounds via palladium catalyzed/norbornene mediated cascade process triggered by ortho CÀ H alkylation, amination or arylation of aryl iodides and covers the literature from 2010-2021.

Over the past decades, reactions involving CH functionalization have become a hot theme in organic transformations because they have a lot of potential for the streamlined synthesis of complex molecules....

In this work, we present a rapid, metal‐free and efficient method for thiocyanation of aromatic amines under microwave irradiation for the synthesis of aryl thiocyanates using inexpensive and nontoxic NH4SCN as thiocyanato source and K2S2O8 as an oxidant. This protocol tolerates a wide range of substituted anilines to provide the corresponding thiocyanated products in good to excellent yields. The features of this strategy include a broad substrate scope, high functional group tolerance, mild reaction conditions, and short reaction time.

Diaryl sulfones are known to show diverse pharmacological properties, which calls for an efficient and convenient method for their synthesis. Here, we report a Cu-catalyzed crosscoupling method for the synthesis of diaryl sulfones from ptoluenesulfonyl hydrazide and aryl boronic acids in the absence of an additional ligand. This synthesis procedure is character-ized by the use of inexpensive and readily available starting materials, mild reaction conditions, and a broad functionality tolerance. Remarkably, various diaryl sulfones have been synthesized in very short reaction times with moderate to excellent yields.