Microwave‐Assisted Metal‐Free C(sp²)−H Thiocyanation of Aromatic Amines

Abstract

In this work, we present a rapid, metal‐free and efficient method for thiocyanation of aromatic amines under microwave irradiation for the synthesis of aryl thiocyanates using inexpensive and nontoxic NH4SCN as thiocyanato source and K2S2O8 as an oxidant. This protocol tolerates a wide range of substituted anilines to provide the corresponding thiocyanated products in good to excellent yields. The features of this strategy include a broad substrate scope, high functional group tolerance, mild reaction conditions, and short reaction time.

Copper-catalyzed ortho-thiocyanation of aromatic amines

“…36 Very recently, our group also reported microwave-assisted metal-free para -thiocyanation of aromatic amines. 37…”