Copper‐Catalyzed Synthesis of Diaryl Sulfones via Cross‐Coupling of Boronic Acids and p‐Toluenesulfonyl Hydrazide

Abstract

Diaryl sulfones are known to show diverse pharmacological properties, which calls for an efficient and convenient method for their synthesis. Here, we report a Cu-catalyzed crosscoupling method for the synthesis of diaryl sulfones from ptoluenesulfonyl hydrazide and aryl boronic acids in the absence of an additional ligand. This synthesis procedure is character-ized by the use of inexpensive and readily available starting materials, mild reaction conditions, and a broad functionality tolerance. Remarkably, various diaryl sulfones have been synthesized in very short reaction times with moderate to excellent yields.