Four experiments were conducted to evaluate the effect of diet and the administration of H2-antagonists in feed on gastric ulcer formation and performance of growing-finishing swine. Pigs receiving a finely ground diet (less than lmm) grew faster (.73 vs .68 kg/d, P less than .01) and had better feed utilization (3.47 vs 3.76, P less than .01) than pigs receiving a cracked corn-based diet. Incidence of ulcers in the esophageal region of the stomach of pigs fed the finely ground diet was greater (P less than .01) than in pigs fed cracked corn. The average daily gain of pigs receiving the finely ground diet was inversely related to ulcer incidence (r = .403, P less than .01, df = 59). The addition of 5, 10, 20 or 100 ppm of the H2-antagonist, metiamide, or 6, 18 or 54 ppm of SK&F 93479 to the finely ground diet did not improve pig performance or affect the incidence of gastric ulceration. The addition of 2, 6 and 18 ppm of SK&F 93479 to a corn-soy diet containing 4.5% alfalfa meal caused a reduction in gastric ulceration (P less than .05) and improved feed utilization by 3.2% (P less than .05). These data suggest that finely ground diets improve the performance of growing-finishing swine, but increase the incidence of ulcers in the esophageal region of the stomach. Severe gastric ulceration adversely affects swine performance. Feeding H2-antagonists does not reduce the ulcerogenic properties of finely ground diets, suggesting factors other than gastric acid secretion are involved in ulcerogenesis. The use of H2-antagonists in corn-soy diets improves feed utilization and reduces ulceration.

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Identification of tuans-6,7-Dihydroxydihydroaldrin and 9-( syn-epoxy )Hydroxy-l,2,3, 4,10,1 O-Hexachloro-6,7-Epoxy-1,4, 4~,5,6,7,8,8a-Octahydro-l ,4-Endo- 5,8-Exo-DimethanonaphthaleneTwo metabolites extracted from sheep urine with exo-dimethanonaphthalene was identified by spectral hexane have been identified. One metabolite, and chemical considerations. The latter compound Ac,O , , FH, S 0, h Ac,O, E1, N ' IhOBH,, EtOH I CI C8 METABOLITE 1 CrO,, Pyridine CrO,, H2SG4 or Ac,O, CH, SO, H Receiced for reciew Jrrly 24, 1969. Accepted October IO. 1969. Refererice to n coiiipuiiy rianie does not imply approval or recommerzduliori of tlie product by tlie U. S. Departriieut of Agricrrlture to the e.dusiori of others tliuf niuy be rirrtable.

Seven sheep were given 165 to 230 microcuries of dieldrin-14C. Three to 14% of the radioactive dose was recovered in the urine over 3-to 6-day periods. This radioactivity was contained in six metabolites, four of which were extracted from urine with hexane and two of which were not. The extraction and isolation of these metabolites are described.That chlorinated hydrocarbon insecticides, such as dieldrin, are accumulated in body fat is well known. However, only recently has the metabolism of dieldrin and related insecticides been reported in animals. Korte and Arent (1965) reported the excretion of dieldrin metabolites in urine and feces of rabbits and rats. They isolated six metabolites from rabbit urine, with one comprising 86% of the total. This metabolite was identified as a trans-diol formed by the addition of water across the epoxide ring. Later,

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