Virginiamycin activity and safety in ruminants

Hedde, R. D.; Shor, Leslie; Quach, R.

doi:10.1007/978-94-009-6604-8_73

“…Ruminal fermentation was not affected by VM supplementation as indicated by changes in total VFA, propionate, valerate and isovalerate concentrations. Our results (except for butyrate) were consistent with several studies (Hedde et al, 1983;Zinn, 1987;Morris et al, 1990;Coe et al, 1999;Valentine et al, 2000;Ives et al, 2002) indicating that the addition of VM had no effect on either the concentration of total volatile fatty acids in the rumen or the proportions of the individual volatile fatty acids (Coe et al, 1999;Valentine et al, 2000). Other studies have reported that VM increases the proportion of propionate relative to other VFA (Hedde et al, 1983;Nagaraja et al, 1995a,b).…”

Section: Discussionsupporting

confidence: 91%

“…Our results (except for butyrate) were consistent with several studies (Hedde et al, 1983;Zinn, 1987;Morris et al, 1990;Coe et al, 1999;Valentine et al, 2000;Ives et al, 2002) indicating that the addition of VM had no effect on either the concentration of total volatile fatty acids in the rumen or the proportions of the individual volatile fatty acids (Coe et al, 1999;Valentine et al, 2000). Other studies have reported that VM increases the proportion of propionate relative to other VFA (Hedde et al, 1983;Nagaraja et al, 1995a,b). This effect of VM was not observed in our experiment, and it might be due to the increased absorption of additional propionate or factors other than VFA production in the animal (Clayton et al, 1999).…”

Section: Discussionsupporting

confidence: 91%

Evaluation of the microbial population in ruminal fluid using real time PCR in steers treated with virginiamycin

Guo¹,

Wang²,

Bu³

et al. 2010

Czech J. Anim. Sci.

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The objective of the present study was to investigate the effects of virginiamycin (VM ) supplementation on ruminal fermentation and microbial populations in steers. Four ruminally cannulated Chinese Luxi steers (BW 559.4 ± 30.1 kg) were used in a crossover design experiment with an experimental period of 28 days. The forage to concentrate ratio of the basal diet was 35:65 on dry matter basis. The experiment consisted of control treatment and treatment with control diet plus VM at a dose of 30 mg/kg concentrate (DM basis). Rumen fluid was collected at 07:30 prefeeding, at 11:30 and 17:30 postfeeding on day 27 and 28. A part of the pooled sample from rumen fluid was transferred to anaerobic culture by a roll-tube technique and analysed for species-specific real-time PCR quantification. The remaining pooled rumen fluid sample was analyzed for pH, VFA, ammonia N and l-lactic acid. The results showed that VM increased the ruminal pH (6.70 vs. 6.63; P < 0.05), but it decreased ammonia nitrogen (4.94 vs. 6.19 mg/100 ml; P < 0.01) and mean counts of amylolytic bacteria and proteolytic bacteria (P < 0.01) as compared to the control. The additive VM did not affect the l-lactic acid concentration (1.39 vs. 1.26 mmol/l) in rumen fluid. Compared to the control, the steers receiving VM have altered a trend of quantification of Selenomonas ruminantium, Anaerovibrio lipolytica, Ruminococcus albus and Streptococcus bovis in rumen fluid (0.05<p<0.1) as compared to the control. However, VM had no significant effect on Lactobacillus spp. (P = 0.41), Butyrivibrio fibrisolvens (P = 0.35), on the genus Ruminococcus (P = 0.25), Ruminococcus flavefaciens (P = 0.52), Prevotella ruminicola (P = 0.54), on the genus Prevotella (P = 0.67) and Megasphaera elsdenii (P = 0.97). In this study, we found that VM had selective effects on ruminal bacteria and influenced ruminal fermentation by changing a part of the specific ruminal bacteria populations.

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“…changing ruminal microbial populations that inhabit the gastrointestinal tract or their metabolic activities (Wagner et al, 2000). The gram-positive bacteria antimicrobial activity and subsequent alterations in ruminal fermentation products are similar to those of monensin (Hedde et al, 1982;Nagaraja et al, 1997 andWagner et al, 2000), namely an increase in propionate at the expense of acetate and methane.…”

mentioning

confidence: 79%

Effect of Salinomycin or Virginiamycin as Feed Additives on Sheep Performance

Moustafa

¹

,

El-Garhy

²

2005

Fayoum Journal of Agricultural Research and Development

0

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Both salinomycin and virginiamycin as feed additives in ruminants diet were nutritionally evaluated through digestibility and feeding trials. Eighteen growing Ossimi lambs, averaging 11.6 ± 0.31 kg in live body weight were assigned on three diets. The diets were (D 1 ) control, (D 2 ) control + 12 ppm salinomycin, and (D 3 ) control + 36 ppm virginiamycin. The control ration consisted of 75% concentrate feed mixture (CFM) + 25% rice straw (RS). Significant differences (P <0.05) for the final body weight gain between control diet (D 1 ) and other two diets were recorded. Insignificant differences were observed between the control diet (D 1 ) and the other two diets containing salinomycin (D 2 ) or virginiamycin (D 3 ) in total dry matter intake (TDMI) or average dry matter intake, g/day (ADMI, g / day), while the digested crude protein (DCP) values recorded for D 2 and D 3 were significantly higher (P < 0.05) then those for D 1 . Insignificant differences were observed in OM, CF, NFE and EE digestibility coefficients between treatments, but the crude protein digestibility (CPD), values were significantly different (P <0.05) for D 2 and D 3 compared to the D 1 . Insignificant differences for TDN and SV were recorded. Concerning the economical evaluation, D 2 or D 3 were very similar and recorded clear advantage comparing to the D 1 .

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“…changing ruminal microbial populations that inhabit the gastrointestinal tract or their metabolic activities (Wagner et al, 2000). The gram-positive bacteria antimicrobial activity and subsequent alterations in ruminal fermentation products are similar to those of monensin (Hedde et al, 1982;Nagaraja et al, 1997 andWagner et al, 2000), namely an increase in propionate at the expense of acetate and methane.…”

mentioning

confidence: 79%

An Organic Source and Elemental Sulfur Inputs for Calcareous Soil Management, Barley Yield and Its Components

Wahdan

¹

,

Hassanien

²

,

Aziz

³

2005

Fayoum Journal of Agricultural Research and Development

0

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Both salinomycin and virginiamycin as feed additives in ruminants diet were nutritionally evaluated through digestibility and feeding trials. Eighteen growing Ossimi lambs, averaging 11.6 ± 0.31 kg in live body weight were assigned on three diets. The diets were (D 1 ) control, (D 2 ) control + 12 ppm salinomycin, and (D 3 ) control + 36 ppm virginiamycin. The control ration consisted of 75% concentrate feed mixture (CFM) + 25% rice straw (RS). Significant differences (P <0.05) for the final body weight gain between control diet (D 1 ) and other two diets were recorded. Insignificant differences were observed between the control diet (D 1 ) and the other two diets containing salinomycin (D 2 ) or virginiamycin (D 3 ) in total dry matter intake (TDMI) or average dry matter intake, g/day (ADMI, g / day), while the digested crude protein (DCP) values recorded for D 2 and D 3 were significantly higher (P < 0.05) then those for D 1 . Insignificant differences were observed in OM, CF, NFE and EE digestibility coefficients between treatments, but the crude protein digestibility (CPD), values were significantly different (P <0.05) for D 2 and D 3 compared to the D 1 . Insignificant differences for TDN and SV were recorded. Concerning the economical evaluation, D 2 or D 3 were very similar and recorded clear advantage comparing to the D 1 .

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Virginiamycin activity and safety in ruminants

Cited by 9 publications

References 2 publications

Evaluation of the microbial population in ruminal fluid using real time PCR in steers treated with virginiamycin

Evaluation of the microbial population in ruminal fluid using real time PCR in steers treated with virginiamycin

Effect of Salinomycin or Virginiamycin as Feed Additives on Sheep Performance

An Organic Source and Elemental Sulfur Inputs for Calcareous Soil Management, Barley Yield and Its Components

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