Bioactive glasses (BGs) have gained great attention owing to their versatile biological properties. Combining BG nanoparticles (BGNPs) with polymeric nanofibers produced nanocomposites of great performance in various biomedical applications especially in regenerative medicine. In this study, a novel nanocomposite nanofibrous system was developed and optimized from cellulose acetate (CA) electrospun nanofibers containing different concentrations of BGNPs. Morphology, IR and elemental analysis of the prepared electrospun nanofibers were determined using SEM, FT-IR and EDX respectively. Electrical conductivity and viscosity were also studied. Antibacterial properties were then investigated using agar well diffusion method. Moreover, biological wound healing capabilities for the prepared nanofiber dressing were assessed using in-vivo diabetic rat model with induced wounds. The fully characterized CA electrospun uniform nanofiber (100–200 nm) with incorporated BGNPs exhibited broad range of antimicrobial activity against gram negative and positive bacteria. The BGNP loaded CA nanofiber accelerated wound closure efficiently by the 10th day. The remaining wound areas for treated rats were 95.7 ± 1.8, 36.4 ± 3.2, 6.3 ± 1.5 and 0.8 ± 0.9 on 1st, 5th, 10th and 15th days respectively. Therefore, the newly prepared BGNP CA nanocomposite nanofiber could be used as a promising antibacterial and wound healing dressing for rapid and efficient recovery.
textile surface in a process that depends mainly on ionic nature of textile surface hydrophilicity and also softener molecules. It is reported that small softener molecules has the ability to penetrate fiber materials resulting in internal plasticization for the fiber material through formation of polymer that reduces its glass transition temperature. The physical positioning of these softener molecules on textile surfaces is crucial. It is dependent s on the hydrophilic character of the surface and ionic nature of softener molecules. Cationic softeners, for instance, are arranged so that the positively charged groups are directed towards partially negatively charges of the fiber material. This orientation offers maximum softness and lubrication properties for the fabric materials [4,5]. Softeners have been reported to produce the C URRENT research was undertaken to develop a new finishing formulation using titanium dioxide nanoparticles (TiO 2 ) homogenously suspended in mixture of cationic softener and herbal oil. Its utilization as multifunctional finishing formulation to cotton based fabrics was investigated. The properties of the treated fabrics were monitored and compared with the untreated one. These properties were include the effect of cationic softener concentration, form of TiO 2 nano particles (mixture of rutile and anatase), type of cotton fabrics (bleached or pre-carboxymethylated) and presence of herbal oil on the properties of the treated cotton fabrics were monitored. Moreover, stability of TiO 2 nanoparticles in such finishing formulation was also determined. The effect of using eco-friendly herbal oil within the same finishing formulation on the antibacterial activities of the treated fabric was also evaluated.The treated fabrics were monitored for UV-protection, self-cleaning and antibacterial properties. Morphology and structure of TiO 2 nanoparticles were characterized using XRD and TEM,. The antibacterial activities of the treated fabrics were evaluated against Staphylococcus aureus (gram-positive) strains and Escherichia coli (gram-negative), the results show significant antibacterial effect mainly against Staphylococcus aureus. In addition, the treated fabrics showed enhanced UV protection and self-cleaning properties with improving softness properties.
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