Reduction of thrombogenicity of PVC-based sodium selective membrane electrodes using heparin-modified chitosan

Badr, Ibrahim H. A.; Gouda, Mohamed; Abdel-Sattar, R.; Sayour, Hossam E. M.

doi:10.1016/j.carbpol.2013.08.087

Cited by 21 publications

(7 citation statements)

References 61 publications

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“…A cell count form SEM micrograghs of five membrane segments of the same membrane yielded an average 13.5 (±5.3) × 10 3 cells/mm 2 , 0.21 (±0.14) × 10 3 cells/mm 2 (n = 5), and 0.15 (±0.05) × 10 3 cells/mm 2 (n = 5) for PVC, CH-CuO and CH-CuO-H membranes, respectively (see data in Figure 10). This indicates that the number of platelets adhered to PVC is about 64-fold higher than that found in CH-CuO and about 90-fold higher than that observed for CH-CuO-H. As expected, SEM micrographs of PVC film showed large platelet aggregates indicating a high thrombogenicity of this membrane [Badr et al (2014)].…”

Section: -Results and Discussionsupporting

confidence: 55%

“…Therefore, the lower detection limit is shifted to high concentrations of sodium. Similarly, shifting in the detection limits to high sodium concentrations was notices in in case of heparin-modified CTA compared to unmodified CTA based membrane electrodes formulated with sodium ionophore-X [Badr, et al, (2005)], as well as in heparin-modified (HCH-PVC) and unmodified (CH-PVC) membrane electrode [Badr, et al, (2014)]. The response slopes of CH-CuO membrane electrodes towards sodium was 55.2.mV/decade and 56.4 for CH-CuO-H which are near-Nernstian.…”

Section: -Results and Discussionmentioning

confidence: 80%

“…Therefore, the adhesion and activation of platelets on a surface is an indicator of its thrombogenicity. Platelet adhesion is routinely used to investigate the interactions between materials and blood in vitro [Badr et al, 2014;Berrocal, et al, (2001);Berrocal, et al, (2000);Espadas-Torre ,et al (1995);Espadas-Torre, et al, (1997);Frost, et al, (2003);Schenfisch, et al, (2000)]. The relative thrombogenicity of different membranes (PVC, CH-CuO-PVC or CH-CuO-H-PVC) were investigated using the platelet adhesion protocol.…”

Section: -Results and Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Enhancing the biocompatibility of Sodium Membrane Electrodes by Using Chitosan-CuO and Chitosan-CuO-Heparin Composite Membranes

Badr

Salim

Salem

et al. 2018

Journal of Scientific Research in Science

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Section: -Results and Discussionsupporting

confidence: 55%

Section: -Results and Discussionmentioning

confidence: 80%

Section: -Results and Discussionmentioning

confidence: 99%

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Enhancing the biocompatibility of Sodium Membrane Electrodes by Using Chitosan-CuO and Chitosan-CuO-Heparin Composite Membranes

Badr

Salim

Salem

et al. 2018

Journal of Scientific Research in Science

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“…Badr et al 38 utilized a heparin-coated chitosan membrane to improve the biocompatibility of the sodium selective membrane electrode based on the highly thrombogenic PVC. The PVC-based sensing lm was sandwiched to chitosan or heparin-coated chitosan to prevent platelet adhesion on the surface.…”

Section: Surface Coating and Physical Blendingmentioning

confidence: 99%

Progress in heparin and heparin-like/mimicking polymer-functionalized biomedical membranes

2014

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Research into the design of heparin and heparin-like/mimicking polymer-functionalized biomedical membranes is of tremendous interest to the biomedical sector in particular and is driven by potential diverse biomedical applications such as blood purification, artificial organs and other clinical medical devices. In this review, we highlight the progress of the recent research and propose potential biomedical applications in the fields of surface heparinization and the heparin-inspired modification of polymeric membranes. We summarize various surface heparinization strategies such as blending, surface coating, grafting, layer-by-layer assembly and mussel-inspired coating. Then, we classify the heparinlike/mimicking polymers and their applications in the design of heparin-mimicking biomedical membranes and draw some conclusions. The general concept of heparin-like/mimicking polymers is usually defined as heparan sulfates or synthetic sulfated/carboxylated polymers with comparable biologically mimicking functionalities as heparin, especially anticoagulant activity. Moreover, the potential biomedical applications and benefits of heparin and heparin-like/mimicking polymer-functionalized membranes in blood purification, artificial organs and tissue engineering are also discussed in each section. The heparin and heparin-like/mimicking polymer-functionalized membranes presented are Chong Cheng obtained his BS degree in 2010 from the Biomedical Engineering, College of Materials Science and Engineering, Sichuan University. Since June 2010, He became a Ph.D candidate in Biomedical Engineering, College of Polymer Science and Engineering, Sichuan University under the supervision of Prof. Changsheng Zhao. He is now doing visiting research work at University of Michigan under the supervision of Prof. Nicholas A. Kotov. His research interests include the blood and cell compatibility of polymeric hydrogels and composite biomaterials, biomedical lms/membranes for tissue engineering and regeneration medicine, self-assembly and biomimetic nanotechnology, and also the studies of biological functionalization and applications of nanomaterials, including nano/micro-gels, hybrid polymeric nanoparticles, carbon nanotubes and graphene. From 2010, his publication includes over 30 high quality papers in top material and chemical journals.

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“…In order to increase chitosan membrane mechanical strength, blending with other polymers such as polydimethylsiloxane (PDMS), polysulfone (PSF), polyvinylalcohol (PVA), and polyethersulfone (PES) has been conducted [5][6][7]. PVA blend was widely developed for medical and pharmacy needs because of its high nontoxic, noncarcinogen, and elasticity characteristics [8][9]. According to Amiji [10] and Ming Chien and Ting-Yu [11] membrane permeability towards creatinine and urea increased in proportion to the increasing of hydrophilic groups in the membrane.…”

Section: ■ Introductionmentioning

confidence: 99%

Grafting of Heparin on Blend Membrane of Citric Acid Crosslinked Chitosan/Polyethylene Glycol-Poly Vinyl Alcohol (PVA-PEG)

et al. 2019

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Heparin, an active sulfate group material, grafted onto blend membrane citric acid cross-linked chitosan/poly (vinyl alcohol)-poly(ethylene glycol) (PVA-PEG) to improve the membrane properties. The physical tests shown that grafting reaction of citric acid crosslinked chitosan increased the mechanical strength and membrane swelling. The permeability test results, it was found that the grafted chitosan membrane was improved permeability of both urea and creatinine as compared to chitosan pure and chitosan crosslinked membrane. The negative charge of the sulphonate group of heparin increased the number of the active side of the carrier in the membrane, which then correlated to the membrane’s permeability process.

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Reduction of thrombogenicity of PVC-based sodium selective membrane electrodes using heparin-modified chitosan

Cited by 21 publications

References 61 publications

Enhancing the biocompatibility of Sodium Membrane Electrodes by Using Chitosan-CuO and Chitosan-CuO-Heparin Composite Membranes

Enhancing the biocompatibility of Sodium Membrane Electrodes by Using Chitosan-CuO and Chitosan-CuO-Heparin Composite Membranes

Progress in heparin and heparin-like/mimicking polymer-functionalized biomedical membranes

Grafting of Heparin on Blend Membrane of Citric Acid Crosslinked Chitosan/Polyethylene Glycol-Poly Vinyl Alcohol (PVA-PEG)

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